[HTML][HTML] Natural products as modulators of Nrf2 signaling pathway in neuroprotection

I Moratilla-Rivera, M Sánchez… - International Journal of …, 2023 - mdpi.com
Neurodegenerative diseases (NDs) affect the West due to the increase in life expectancy.
Nervous cells accumulate oxidative damage, which is one of the factors that triggers and …

[HTML][HTML] Neuroprotective mechanisms of ginsenoside Rb1 in central nervous system diseases

L Gong, J Yin, Y Zhang, R Huang, Y Lou… - Frontiers in …, 2022 - frontiersin.org
Panax ginseng and Panax notoginseng, two well-known herbs with enormous medical
value in Asian countries, have a long usage history in China for the therapy of some …

DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress

B Wang, C Wu, Z Chen, P Zheng, Y Liu… - Acta pharmacologica …, 2021 - nature.com
Abstract DL-3-n-Butylphthalide (DL-NBP), a small molecular compound extracted from the
seeds of Apium graveolens Linn (Chinese celery), has been shown to exert neuroprotective …

[HTML][HTML] Ginsenoside and its therapeutic potential for cognitive impairment

H Feng, M Xue, H Deng, S Cheng, Y Hu, C Zhou - Biomolecules, 2022 - mdpi.com
Cognitive impairment (CI) is one of the major clinical features of many neurodegenerative
diseases. It can be aging-related or even appear in non-central nerve system (CNS) …

Nrf2 pathway in age-related neurological disorders: insights into MicroRNAs

S Paladino, A Conte, R Caggiano… - Cellular Physiology and …, 2018 - karger.com
A general hallmark of neurological diseases is the loss of redox homeostasis that triggers
oxidative damages to biomolecules compromising neuronal function. Under physiological …

Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling

Z Kazmi, S Zeeshan, A Khan, S Malik, A Shehzad… - Neurotoxicology, 2020 - Elsevier
Epilepsy is a complex and multifactorial neurodegenerative disease described by recurrent
seizures. Oxidative stress and dysregulation of brain-derived neurotrophic factor (BDNF) …

[HTML][HTML] Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax …

Z Lin, R Xie, C Zhong, J Huang, P Shi, H Yao - Journal of ginseng research, 2022 - Elsevier
Abstract Ginsenoside Rb 1 (Rb 1), one of the most important ingredients in Panax ginseng
Meyer, has been confirmed to have favorable activities, including reducing antioxidative …

The neuroprotective effect of ginsenoside Rb1 on the cerebral cortex changes induced by aluminium chloride in a mouse model of Alzheimer's disease: A histological …

AM Shalaby, SM Alnasser, DA Khairy… - Journal of Chemical …, 2023 - Elsevier
Alzheimer's disease (AD) is one of the most common types of dementia among
neurodegenerative disorders characterized by attention deficits and memory loss. Panax …

[HTML][HTML] Natural medicines for the treatment of epilepsy: bioactive components, pharmacology and mechanism

LY He, MB Hu, RL Li, R Zhao, LH Fan, L He… - Frontiers in …, 2021 - frontiersin.org
Epilepsy is a chronic disease that can cause temporary brain dysfunction as a result of
sudden abnormal discharge of the brain neurons. The seizure mechanism of epilepsy is …

Pharmacological modulation of autophagy for Epilepsy therapy: opportunities and obstacles

W Chen, J Zhang, Y Zhang, J Zhang, W Li, L Sha… - Drug Discovery …, 2023 - Elsevier
Epilepsy (EP) is a long-term neurological disorder characterized by neuroinflammatory
responses, neuronal apoptosis, imbalance between excitatory and inhibitory …