At the turn of the twenty-first century, fundamental changes took place in the understanding
of the structure and function of proteins and then in the appreciation of the intracellular …

This review deals with two important concepts—protein intrinsic disorder and proteinaceous
membrane-less organelles (PMLOs). The past 20 years have seen an upsurge of scientific …

Intrinsically disordered proteins (IDPs) are ubiquitous proteins that are disordered entirely or
partly and play important roles in diverse biological phenomena. Their structure dynamically …

The proposal that coupled folding to binding is not an obligatory mechanism for intrinsically
disordered (ID) proteins was put forward 10 years ago. The notion of fuzziness implies that …

Intrinsically disordered proteins (IDPs) are prevalent in eukaryotes, performing signaling and
regulatory functions. Often associated with human diseases, they constitute drug …

An increasing number of protein interaction domains and their targets are being found to be
intrinsically disordered proteins (IDPs). The corresponding target recognition mechanisms …

In this review, we detail the most common experimental approaches to assess and
characterize protein intrinsic structural disorder, with the notable exception of NMR and EPR …

Abstract Measles, Nipah and Hendra viruses are severe human pathogens within the
Paramyxoviridae family. Their non-segmented, single-stranded, negative-sense RNA …

Henipaviruses are BSL-4 zoonotic pathogens responsible in humans for severe
encephalitis. Their V protein is a key player in the evasion of the host innate immune …

Macroautophagy/autophagy is an essential cellular response in the fight against intracellular
pathogens. Although some viruses can escape from or utilize autophagy to ensure their own …