New antiarrhythmic drugs for treatment of atrial fibrillation

D Dobrev, S Nattel - The Lancet, 2010 - thelancet.com
Inadequacies in current therapies for atrial fibrillation have made new drug development
crucial. Conventional antiarrhythmic drugs increase the risk of ventricular proarrhythmia. In …

Atrial fibrosis and substrate based characterization in atrial fibrillation: time to move forwards

JX Quah, D Dharmaprani, K Tiver… - Journal of …, 2021 - Wiley Online Library
Atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia in clinical
practice. However, current therapeutic interventions for atrial fibrillation have limited clinical …

Risk for incident atrial fibrillation in patients who receive antihypertensive drugs: a nested case–control study

BA Schaer, C Schneider, SS Jick, D Conen… - Annals of internal …, 2010 - acpjournals.org
Background: Different antihypertensive drug classes may alter risk for atrial fibrillation. Some
studies suggest that drugs that interfere with the renin–angiotensin system may be favorable …

Novel approaches for pharmacological management of atrial fibrillation

JR Ehrlich, S Nattel - Drugs, 2009 - Springer
In the light of the progressively increasing prevalence of atrial fibrillation (AF), medical
awareness of the need to develop improved therapeutic approaches for the arrhythmia has …

n-3 Polyunsaturated fatty acids alter expression of fibrotic and hypertrophic genes in a dog model of atrial cardiomyopathy

A Ramadeen, G Laurent, CC dos Santos, X Hu… - Heart Rhythm, 2010 - Elsevier
BACKGROUND: We previously showed that omega-3 polyunsaturated fatty acids (PUFAs)
reduce vulnerability to atrial fibrillation (AF). The mechanisms underlying this effect are …

Doppler tissue evaluation of atrial conduction properties in patients with non-alcoholic fatty-liver disease

O Ozveren, C Izgi, E Eroglu, MA Simsek… - Ultrasonic …, 2016 - journals.sagepub.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
in clinical practice, and there is an increasing trend in its prevalence in the general …

[HTML][HTML] Upstream therapy for atrial fibrillation prevention: the role of sacubitril/valsartan

R De Vecchis, A Paccone, M Di Maio - Cardiology Research, 2020 - ncbi.nlm.nih.gov
The therapy or prevention of atrial fibrillation (AF) is defined as upstream therapy when
conducted with the use of drugs, eg, angiotensin-converting enzyme inhibitors (ACEIs) …

The role of brain natriuretic peptide in atrial fibrillation: a substudy of the Substrate Modification with Aggressive Blood Pressure Control for Atrial Fibrillation (SMAC-AF …

W Weng, R Choudhury, J Sapp, A Tang… - BMC Cardiovascular …, 2021 - Springer
Background Catheter ablation is an established therapy for atrial fibrillation but is limited by
recurrence; efforts have been made to identify biomarkers that predict recurrence. We …

Cardiac dysfunction in the CABG patient

S Siribaddana - Current opinion in pharmacology, 2012 - Elsevier
Coronary revascularization with conventional CABG has the best evidence for improving
outcome in patients with ischemic heart disease. Three main complications after CABG are …

Efficacy and safety of prescription omega-3-acid ethyl esters for the prevention of recurrent symptomatic atrial fibrillation: a prospective study

CM Pratt, JA Reiffel, KA Ellenbogen, GV Naccarelli… - American heart …, 2009 - Elsevier
BACKGROUND: Atrial fibrillation (AF) continues to be one of the most common cardiac
problems, placing an expanding burden on the public health system. In several …