Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …

Abstract Statins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, are currently
the most effective lipid-lowering drugs, effectively reducing the plasma total cholesterol and …

Purpose of review The purpose of this study is to analyze the current evidence regarding the
use of statins in patients with chronic liver disease and cirrhosis. Recent findings Chronic …

Proprotein convertase subtilisin/kexin type 9 (PCSK-9) is a serine protease of the proprotien
convertase (PC) family that has profound effects on plasma low density lipoprotein …

Background: Understanding the variability across the human population with respect to
toxicodynamic responses after exposure to chemicals, such as environmental toxicants or …

Many now believe the holy grail for the next stage of therapeutic advance surrounds the
development of disease-modifying approaches aimed at intercepting the year-on-year …

Lipid metabolism disorders contribute to hyperlipidemia and hepatic steatosis. It is ideal to
develop drugs simultaneous improving both hyperlipidemia and hepatic steatosis …

The potential effects of the environmental residues of Atorvastatin (ATV) as a widely used
antilipemic agent on aquatic organisms deserve more investigations because of its high …

Introduction We have investigated the possible effects and mechanism of atorvastatin, a
statin, and/or probucol, a powerful antioxidant used to lower cholesterol before 1995, on the …

The epidemic of obesity, type 2 diabetes and nonalcoholic liver disease (NAFLD) favors
drug consumption, which augments the risk of adverse events including liver injury. For …