Background Many in vitro studies have shown that adenosine (Ado) can induce vascular
endothelial growth factor (VEGF) mRNA and protein expression and stimulate endothelial …

The brain has evolved several endogenous mechanisms to protect itself from the deleterious
consequences of stroke. One of those endogenous neuroprotective systems is centered on …

It is known that angiogenic factors are induced in brain by ischaemia, and new vessel
formation is correlated with better prognosis in patients of stroke. However, the role of …

In patients with prior stroke or transient ischaemic attack, anti-platelet treatment with
dipyridamole substantially reduced stroke recurrence, with a beneficial effect comparable to …

The mechanisms involved in the blockade of proliferation in confluent endothelial cells are
insufficiently understood. In this regard, the continuity of intercellular junctions appears to be …

Background. Long-term peritoneal dialysis (PD) is associated with peritoneal fibrosis and
loss of function. It has been shown that activation of the adenosine A2A receptor (A2AR) …

Aims: A meta-analysis of 13 randomized placebo-controlled trials demonstrated a benefit for
dipyridamole therapy, particularly with longer duration of treatment. Although the mechanism …

We tested whether increased endogenous adenosine produced by the adenosine kinase
inhibitor GP-515 (Metabasis Therapeutics) can induce vascular endothelial growth factor …

Adenosine is produced primarily by the metabolism of ATP and mediates its physiological
actions by interacting primarily with adenosine receptors (ARs) on the plasma membranes of …

The objective of this study was to investigate whether synthesis of vascular endothelial
growth factor (VEGF), a major mitogen for vascular endothelial cells, was induced by a cell …