Heme-oxygenase is the enzyme responsible for degradation of endogenous iron
protoporphyirin heme; it catalyzes the reaction's rate-limiting step, resulting in the release of …

Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes,
playing detrimental roles in the pathogenesis of atherosclerosis and cardiovascular …

The discovery of adipokines has revealed adipose tissue as a central node in the interorgan
crosstalk network, which mediates the regulation of multiple organs and tissues. Adipose …

Numerous clinical and population studies have demonstrated that increased serum bilirubin
levels protect against cardiovascular and metabolic diseases such as obesity and diabetes …

Adipose tissue is a major endocrine organ, releasing signaling and mediator proteins,
termed adipokines, via which adipose tissue communicates with other organs. Expansion of …

The global epidemic of obesity continues unabated with sequelae of diabetes and metabolic
syndrome. This review reflects the dramatic increase in research on the role of increased …

Diabetes and obesity are chronic conditions associated with elevated oxidative/inflammatory
activities with a continuum of tissue insults leading to more severe cardiometabolic and …

Obesity-associated inflammation causes insulin resistance. Obese adipose tissue displays
hypertrophied adipocytes and increased expression of the cannabinoid-1 receptor. Cobalt …

Obesity-induced endoplasmic reticulum (ER) stress causes chronic inflammation in adipose
tissue and steatosis in the liver, and eventually leads to insulin resistance and type 2 …

Obesity-mediated metabolic syndrome remains the leading cause of death worldwide.
Among many potential targets for pharmacological intervention, a promising strategy …