The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Fibrillar collagen is the most abundant extracellular matrix (ECM) constituent which
maintains the structure of most interstitial tissues and organs, including skin, gut, and breast …

We developed a methodology using 3D bio-printing technology to create a functional in vitro
vascular channel with perfused open lumen using only cells and biological matrices. The …

The extracellular matrix (ECM) is critical for all aspects of vascular biology. In concert with
supporting cells, endothelial cells (ECs) assemble a laminin-rich basement membrane …

We show that endothelial cell (EC)–generated vascular guidance tunnels (ie, matrix spaces
created during tube formation) serve as conduits for the recruitment and motility of pericytes …

The von Willebrand A (VWA) domain is a well-studied domain involved in cell adhesion, in
extracellular matrix proteins, and in integrin receptors. A number of human diseases arise …

Regulators of G protein signaling (RGS) and RGS-like proteins are a family (> 30 members)
of highly diverse, multifunctional signaling proteins that bind directly to activated Gα …

To achieve the task of fabricating functional tissues, scaffold materials that can be sufficiently
vascularized to mimic functionality and complexity of native tissues are yet to be developed …

Anthrax toxin consists of three nontoxic proteins that self-assemble at the surface of receptor-
bearing mammalian cells or in solution, yielding a series of toxic complexes. Two of the …

Bacillus anthracis secretes two bipartite toxins thought to be involved in anthrax
pathogenesis and resulting death of the host. The current model for intoxication is that …