Developmental origins of metabolic diseases

DJ Hoffman, TL Powell, ES Barrett… - Physiological …, 2021 - journals.physiology.org
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …

[HTML][HTML] Maternal–fetal nutrient transport in pregnancy pathologies: the role of the placenta

KE Brett, ZM Ferraro, J Yockell-Lelievre… - International journal of …, 2014 - mdpi.com
Appropriate in utero growth is essential for offspring development and is a critical contributor
to long-term health. Fetal growth is largely dictated by the availability of nutrients in maternal …

Regulation of nutrient transport across the placenta

S Lager, TL Powell - Journal of pregnancy, 2012 - Wiley Online Library
Abnormal fetal growth, both growth restriction and overgrowth, is associated with perinatal
complications and an increased risk of metabolic and cardiovascular disease later in life …

[HTML][HTML] Placental responses to changes in the maternal environment determine fetal growth

KG Dimasuay, P Boeuf, TL Powell… - Frontiers in physiology, 2016 - frontiersin.org
Placental responses to maternal perturbations are complex and remain poorly understood.
Altered maternal environment during pregnancy such as hypoxia, stress, obesity, diabetes …

Lipid metabolism during pregnancy and its implications for fetal growth

E Herrera, H Ortega-Senovilla - Current pharmaceutical …, 2014 - ingentaconnect.com
More glucose crosses the placenta than any other substrate, but correlations between its
concentration in maternal plasma and fetal growth are not found consistently. The …

Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus

VE Murphy, R Smith, WB Giles, VL Clifton - Endocrine reviews, 2006 - academic.oup.com
The environment in which the fetus develops is critical for its survival and long-term health.
The regulation of normal human fetal growth involves many multidirectional interactions …

Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches

T Jansson, TL Powell - Clinical science, 2007 - portlandpress.com
Adverse influences during fetal life alter the structure and function of distinct cells, organ
systems or homoeostatic pathways, thereby 'programming'the individual for an increased …

[HTML][HTML] Maternal and fetal lipid metabolism under normal and gestational diabetic conditions

E Herrera, G Desoye - Hormone molecular biology and clinical …, 2016 - degruyter.com
Maternal lipids are strong determinants of fetal fat mass. Here we review the overall lipid
metabolism in normal and gestational diabetes mellitus (GDM) pregnancies. During early …

Maternal undernutrition influences placental-fetal development

L Belkacemi, DM Nelson, M Desai… - Biology of …, 2010 - academic.oup.com
Maternal nutrition during pregnancy has a pivotal role in the regulation of placental-fetal
development and thereby affects the lifelong health and productivity of offspring. Suboptimal …

[HTML][HTML] Oocyte maturation and quality: role of cyclic nucleotides

RB Gilchrist, AM Luciano, D Richani, HT Zeng… - …, 2016 - rep.bioscientifica.com
The developing fetus requires substantial amounts of fatty acids to support rapid cellular
growth and activity. Although the fatty acid composition delivered to the fetus is largely …