[PDF][PDF] SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19

A Grifoni, J Sidney, R Vita, B Peters, S Crotty… - Cell host & …, 2021 - cell.com
Over the past year, numerous studies in the peer reviewed and preprint literature have
reported on the virological, epidemiological and clinical characteristics of the coronavirus …

Fundamentals and methods for T‐and B‐cell epitope prediction

JL Sanchez-Trincado… - Journal of …, 2017 - Wiley Online Library
Adaptive immunity is mediated by T‐and B‐cells, which are immune cells capable of
developing pathogen‐specific memory that confers immunological protection. Memory and …

[PDF][PDF] Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

A Tarke, J Sidney, CK Kidd, JM Dan, SI Ramirez… - Cell Reports …, 2021 - cell.com
T cells are involved in control of SARS-CoV-2 infection. To establish the patterns of
immunodominance of different SARS-CoV-2 antigens and precisely measure virus-specific …

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

J Mateus, A Grifoni, A Tarke, J Sidney, SI Ramirez… - Science, 2020 - science.org
Many unknowns exist about human immune responses to the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2–reactive CD4+ T cells have …

[PDF][PDF] Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals

A Grifoni, D Weiskopf, SI Ramirez, J Mateus, JM Dan… - Cell, 2020 - cell.com
Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development,
interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of …

[HTML][HTML] COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning

E Ong, MU Wong, A Huffman, Y He - Frontiers in immunology, 2020 - frontiersin.org
To ultimately combat the emerging COVID-19 pandemic, it is desired to develop an effective
and safe vaccine against this highly contagious disease caused by the SARS-CoV-2 …

Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning

DM Mason, S Friedensohn, CR Weber… - Nature Biomedical …, 2021 - nature.com
The optimization of therapeutic antibodies is time-intensive and resource-demanding,
largely because of the low-throughput screening of full-length antibodies (approximately 1× …

T cells from patients with Parkinson's disease recognize α-synuclein peptides

D Sulzer, RN Alcalay, F Garretti, L Cote, E Kanter… - Nature, 2017 - nature.com
Genetic studies have shown the association of Parkinson's disease with alleles of the major
histocompatibility complex,,. Here we show that a defined set of peptides that are derived …

Linking neuroinflammation and neurodegeneration in Parkinson's disease

G Gelders, V Baekelandt… - Journal of immunology …, 2018 - Wiley Online Library
Neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease
(AD) impose a pressing burden on our developed and consequently aging society …

[HTML][HTML] The immune epitope database and analysis resource in epitope discovery and synthetic vaccine design

W Fleri, S Paul, SK Dhanda, S Mahajan, X Xu… - Frontiers in …, 2017 - frontiersin.org
The task of epitope discovery and vaccine design is increasingly reliant on bioinformatics
analytic tools and access to depositories of curated data relevant to immune reactions and …