Sickle cell disease (SCD) results from a single mutation in the β-globin gene, leading to
clinical manifestations that extend far beyond the mutated hemoglobin in red blood cells …

Background: Inherited hemoglobinopathies led by Sickle Cell Disease (SCD) are key
contributors to the anaemia burden in Sub-Saharan Africa (SSA). In Tanzania, an estimated …

A anemia falciforme (AF) é uma anemia hemolítica hereditária que acarreta ao portador
manifestações clínicas complexas e diversificadas. Na AF o estresse oxidativo é um dos …

Background Haemolysis occurs in a number of haematologic and non-haematologic
diseases, including sickle cell disease, malaria and sepsis. Elevated extracellular …

Inflammation is a normal physiological response to the invasive action of pathogens or
tissue injury, which trigger a rapid inflammatory response initiated by the recruitment of cells …

Sickle cell disease (SCD) is an inherited disorders in which red blood cells (RBCs) have a
variant of the hemoglobin (Hb), named HbS. It is caused by the substitution of a single amino …

The molecular mechanisms governing gamma-globin expression in a subset of fetal
hemoglobin (alpha 2: gamma 2; HbF) expressing red blood cells (F-cells) and the …

1.1 Background SCD411 is a proposed biosimilar of Eylea® having aflibercept as the active
substance that binds to vascular endothelial growth factor A (VEGF-A) and produced in …

In several systems, hydroxyurea has been shown to trigger nitric oxide (NO) release or
activation of NO synthase (NOS). To elucidate this duality in its pharmacological effects …

* Running title: HC activates endothelial PDE4A inhibiting sickle RBC adhesion aThese
authors contributed equally to this work bTo whom correspondence should be addressed …