The aetiology and molecular landscape of insulin resistance

DE James, J Stöckli, MJ Birnbaum - Nature Reviews Molecular Cell …, 2021 - nature.com
Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …

Insulin signaling in health and disease

AR Saltiel - The Journal of clinical investigation, 2021 - Am Soc Clin Investig
The molecular mechanisms of cellular insulin action have been the focus of much
investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in …

Pathophysiology of the metabolic syndrome

E McCracken, M Monaghan, S Sreenivasan - Clinics in dermatology, 2018 - Elsevier
The metabolic syndrome—otherwise called syndrome X, insulin resistance syndrome,
Reaven syndrome, and “the deadly quartet”—is the name given to the aggregate of clinical …

[HTML][HTML] New horizons in diabetic neuropathy: mechanisms, bioenergetics, and pain

EL Feldman, KA Nave, TS Jensen, DLH Bennett - Neuron, 2017 - cell.com
Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic
complications create a substantial burden on both the afflicted patients and society as a …

A minireview of quercetin: from its metabolism to possible mechanisms of its biological activities

HG Ulusoy, N Sanlier - Critical Reviews in Food Science and …, 2020 - Taylor & Francis
Quercetin, one of the most taken flavonoid with diet, belongs to the family of flavonols in
which kaempferol and myricetin are also found. Quercetin occurs as a glycoside (with linked …

Structure, function and regulation of mammalian glucose transporters of the SLC2 family

GD Holman - Pflügers Archiv-European Journal of Physiology, 2020 - Springer
The SLC2 genes code for a family of GLUT proteins that are part of the major facilitator
superfamily (MFS) of membrane transporters. Crystal structures have recently revealed how …

Utilisation of dietary carbohydrates in farmed fishes: new insights on influencing factors, biological limitations and future strategies

BS Kamalam, F Medale, S Panserat - Aquaculture, 2017 - Elsevier
Carbohydrates are the most abundant class of energy yielding nutrients which is
economically indispensable in commercial fish feed formulations. But, the ability of farmed …

Glucose transporters: physiological and pathological roles

AM Navale, AN Paranjape - Biophysical reviews, 2016 - Springer
Glucose is a primary energy source for most cells and an important substrate for many
biochemical reactions. As glucose is a need of each and every cell of the body, so are the …

[HTML][HTML] Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training

CK Roberts, AL Hevener, RJ Barnard - Comprehensive physiology, 2013 - ncbi.nlm.nih.gov
Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

Regulation of skeletal muscle glucose transport and glucose metabolism by exercise training

PL Evans, SL McMillin, LA Weyrauch, CA Witczak - Nutrients, 2019 - mdpi.com
Aerobic exercise training and resistance exercise training are both well-known for their
ability to improve human health; especially in individuals with type 2 diabetes. However …