Autism spectrum disorders (ASD) are a group of disorders characterized by impairment in
social communication and repetitive and stereotyped behaviors. ASD etiology is very …

Dopamine (DA), as one of the major neurotransmitters in the central nervous system (CNS)
and periphery, exerts its actions through five types of receptors which belong to two major …

Multitarget anti-Alzheimer agents are the focus of very intensive research. Through a
comprehensive bibliometric analysis of the publications in the period 1990–2020, we have …

Background Blood-brain barrier (BBB) disruption and gut microbiota dysbiosis play crucial
roles in Alzheimer's disease (AD). Lipopolysaccharide (LPS) stimulation triggered by gut …

Despite the better understanding of the mechanisms underlying Alzheimer's Disease (AD)
and launched clinical trials, no AD-modifying treatment based on a synthetic drug has been …

Neuroinflammation is one of the major pathological factors leading to Alzheimer's disease
(AD). The role of microglial cells in neuroinflammation associated with AD has been known …

Among the serotonin receptors, one of the most recently discovered 5-HT6 subtype is an
important protein target and its ligands may play a key role in the innovative treatment of …

This research allowed us to find the first highly potent 5-HT 6/5-HT 2A receptor (5-HT 6/5-HT
2A R) dual antagonists in a group of 1, 3, 5-triazine compounds as a result of an exit beyond …

Abstract Serotonin (5-HT) biological functions are complex and multifaceted. It controls
almost all central nervous system (CNS) regions from cell bodies confined in the brainstem …

The hippocampal region receives a dense serotoninergic innervation originating from both
medial and dorsal raphe nuclei. This innervation regulates hippocampal activity through the …