Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by
lysosomal degradation pathways. Autophagy is implicated in various biological processes …

Background Ageing is the inevitable time-dependent decline in physiological organ function
that eventually leads to death. Age is a major risk factor for many of the most common …

Huntington's disease (HD) is a fatal, dominantly inherited neurodegenerative disorder
caused by CAG trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Since the …

The term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated
through a vast network of biochemical pathways. This requires the regulated control of …

Neurological disorders such as stroke, Alzheimer's and Parkinson's diseases are associated
with high morbidity and mortality, and few or no effective options are available for their …

Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …

The intronic GGGGCC hexanucleotide repeat expansion in chromosome 9 open reading
frame 72 (C9ORF72) is a prevalent genetic abnormality identified in both frontotemporal …

Perturbed neuronal proteostasis is a salient feature shared by both aging and protein
misfolding disorders. The proteostasis network controls the health of the proteome by …

Neurodegenerative diseases, characterized by a progressive loss of brain function, affect
the lives of millions of individuals worldwide. The complexity of the brain poses a challenge …

In eukaryotic cells, the endoplasmic reticulum (ER) is the cell compartment involved in
secretory protein translocation and quality control of secretory protein folding. Different …