[HTML][HTML] The importance of drug titration in the management of patients with epilepsy

LG Seiden, GS Connor - Epilepsy & Behavior, 2022 - Elsevier
The variable response to antiseizure medication (ASM) treatment and the numerous drug-
and patient-related factors that must be considered when initiating therapy make drug …

Movement disorders associated with antiseizure medications: A systematic review

DJ Zhou, S Pavuluri, I Snehal, CM Schmidt… - Epilepsy & Behavior, 2022 - Elsevier
New-onset movement disorders have been frequently reported in association with the use of
antiseizure medications (ASMs). The frequency of specific motor manifestations and the …

[HTML][HTML] Factors affecting adherence to antiepileptic medications among Sudanese individuals with epilepsy: A cross-sectional survey

MA Elsayed, NM El-Sayed, S Badi… - Journal of family …, 2019 - journals.lww.com
Background: Nonadherence to medication is widespread in epilepsy and other chronic
diseases. Studies reporting adherence to antiepileptic medications are very limited in …

[HTML][HTML] The efficacy and safety of third-generation antiseizure medications and non-invasive brain stimulation to treat refractory epilepsy: a systematic review and …

Y Yang, Y Shangguan, X Wang, R Liu, Z Shen… - Frontiers in …, 2024 - frontiersin.org
Background The new antiseizure medications (ASMs) and non-invasive brain stimulation
(NIBS) are controversial in controlling seizures. So, this network meta-analysis aimed to …

[HTML][HTML] Therapeutic efficacy of voltage-gated sodium channel inhibitors in epilepsy

J Agbo, ZG Ibrahim, SY Magaji, YB Mutalub… - Acta Epileptologica, 2023 - Springer
Epilepsy is a neurological disease characterized by excessive and abnormal hyper-
synchrony of electrical discharges of the brain and a predisposition to generate epileptic …

Eslicarbazepine acetate in epilepsies with focal and secondary generalised seizures: systematic review of current evidence

LM Willems, JP Zöllner, E Paule… - Expert review of …, 2018 - Taylor & Francis
Introduction: Eslicarbazepine acetate (ESL) is a third-generation antiepileptic drug (AED)
approved for adjunctive treatment in adults, children, and adolescents with focal-onset …

Onset of efficacy and adverse events during Cenobamate titration period

BJ Steinhoff, E Ben‐Menachem… - Acta Neurologica …, 2022 - Wiley Online Library
Objectives Cenobamate is an antiseizure medication (ASM) approved in Europe as
adjunctive therapy for adults with inadequately controlled focal seizures. This post hoc …

Exposure‐safety and efficacy response relationships and population pharmacokinetics of eslicarbazepine acetate

BE Gidal, MP Jacobson… - Acta Neurologica …, 2018 - Wiley Online Library
Objectives Eslicarbazepine acetate (ESL) is a once‐daily (QD) oral antiepileptic drug (AED)
for focal‐onset seizures (FOS). Pharmacokinetic (PK) and pharmacodynamic (PD) models …

Development and validation of a specific and sensitive LC–MS/MS method for determination of eslicarbazepine in human plasma and its clinical pharmacokinetic …

T Li, B Huang, D Li, Y Zhu, L Ding, C Shu - Journal of Chromatography B, 2019 - Elsevier
In this work, we developed and validated the specific, sensitive and simple LC–MS/MS
method for quantification of eslicarbazepine in human plasma. The analyte samples were …

Individual-level response adaptive crossover trial design for epilepsy: structure and simulation

WT Kerr, X Zhang, JM Stern - medRxiv, 2020 - medrxiv.org
Trials of antiseizure medications involve static group assignments for treatments with pre-
specified durations. We propose a response-adaptive crossover design using basic …