Cytokines: from clinical significance to quantification

C Liu, D Chu, K Kalantar‐Zadeh, J George… - Advanced …, 2021 - Wiley Online Library
Cytokines are critical mediators that oversee and regulate immune and inflammatory
responses via complex networks and serve as biomarkers for many diseases. Quantification …

Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

[HTML][HTML] Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy

X Han, T Xu, Q Fang, H Zhang, L Yue, G Hu, L Sun - Redox Biology, 2021 - Elsevier
Activated microglia are an important type of innate immune cell in the brain, and they secrete
inflammatory cytokines into the extracellular milieu, exert neurotoxicity to surrounding …

Emerging principles of cytokine pharmacology and therapeutics

RA Saxton, CR Glassman, KC Garcia - Nature Reviews Drug Discovery, 2023 - nature.com
Cytokines are secreted signalling proteins that play essential roles in the initiation,
maintenance and resolution of immune responses. Although the unique ability of cytokines …

Polymeric particle-based therapies for acute inflammatory diseases

ER Brannon, MV Guevara, NJ Pacifici, JK Lee… - Nature Reviews …, 2022 - nature.com
Acute inflammation is essential for initiating and coordinating the body's response to injuries
and infections. However, in acute inflammatory diseases, inflammation is not resolved but …

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease

X Han, S Sun, Y Sun, Q Song, J Zhu, N Song, M Chen… - Autophagy, 2019 - Taylor & Francis
Aging-related, nonresolving inflammation in both the central nervous system (CNS) and
periphery predisposes individuals to the development of neurodegenerative disorders …

Systematic review of safety and efficacy of IL-1-targeted biologics in treating immune-mediated disorders

DD Arnold, A Yalamanoglu, O Boyman - Frontiers in immunology, 2022 - frontiersin.org
Background The cytokine interleukin (IL)-1 plays a pivotal role in immune-mediated
disorders, particularly in autoinflammatory diseases. Targeting this cytokine proved to be …

Microstructure, pathophysiology, and potential therapeutics of COVID‐19: a comprehensive review

SP Singh, M Pritam, B Pandey… - Journal of medical …, 2021 - Wiley Online Library
There have been over seven million cases and almost 413 372 deaths globally due to the
novel coronavirus (2019‐nCoV) associated disease COVID‐19, as of 11 June 2020 …

Senescence and the tumor-immune landscape: Implications for cancer immunotherapy

L Chibaya, J Snyder, M Ruscetti - Seminars in cancer biology, 2022 - Elsevier
Cancer therapies, including conventional chemotherapy, radiation, and molecularly targeted
agents, can lead to tumor eradication through a variety of mechanisms. In addition to their …

Cytokine imbalance in schizophrenia. from research to clinic: potential implications for treatment

M Reale, E Costantini, NH Greig - Frontiers in psychiatry, 2021 - frontiersin.org
Cytokines are one of the most important components of the immune system. They
orchestrate the brain's response to infectious and other exogenous insults and are crucial …