Cytokines: from clinical significance to quantification
Cytokines are critical mediators that oversee and regulate immune and inflammatory
responses via complex networks and serve as biomarkers for many diseases. Quantification …
responses via complex networks and serve as biomarkers for many diseases. Quantification …
Dopamine, immunity, and disease
B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …
regulating many processes including reward, movement, and cognition. Dopamine also …
[HTML][HTML] Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy
X Han, T Xu, Q Fang, H Zhang, L Yue, G Hu, L Sun - Redox Biology, 2021 - Elsevier
Activated microglia are an important type of innate immune cell in the brain, and they secrete
inflammatory cytokines into the extracellular milieu, exert neurotoxicity to surrounding …
inflammatory cytokines into the extracellular milieu, exert neurotoxicity to surrounding …
Emerging principles of cytokine pharmacology and therapeutics
Cytokines are secreted signalling proteins that play essential roles in the initiation,
maintenance and resolution of immune responses. Although the unique ability of cytokines …
maintenance and resolution of immune responses. Although the unique ability of cytokines …
Polymeric particle-based therapies for acute inflammatory diseases
ER Brannon, MV Guevara, NJ Pacifici, JK Lee… - Nature Reviews …, 2022 - nature.com
Acute inflammation is essential for initiating and coordinating the body's response to injuries
and infections. However, in acute inflammatory diseases, inflammation is not resolved but …
and infections. However, in acute inflammatory diseases, inflammation is not resolved but …
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease
X Han, S Sun, Y Sun, Q Song, J Zhu, N Song, M Chen… - Autophagy, 2019 - Taylor & Francis
Aging-related, nonresolving inflammation in both the central nervous system (CNS) and
periphery predisposes individuals to the development of neurodegenerative disorders …
periphery predisposes individuals to the development of neurodegenerative disorders …
Systematic review of safety and efficacy of IL-1-targeted biologics in treating immune-mediated disorders
DD Arnold, A Yalamanoglu, O Boyman - Frontiers in immunology, 2022 - frontiersin.org
Background The cytokine interleukin (IL)-1 plays a pivotal role in immune-mediated
disorders, particularly in autoinflammatory diseases. Targeting this cytokine proved to be …
disorders, particularly in autoinflammatory diseases. Targeting this cytokine proved to be …
Microstructure, pathophysiology, and potential therapeutics of COVID‐19: a comprehensive review
There have been over seven million cases and almost 413 372 deaths globally due to the
novel coronavirus (2019‐nCoV) associated disease COVID‐19, as of 11 June 2020 …
novel coronavirus (2019‐nCoV) associated disease COVID‐19, as of 11 June 2020 …
Senescence and the tumor-immune landscape: Implications for cancer immunotherapy
L Chibaya, J Snyder, M Ruscetti - Seminars in cancer biology, 2022 - Elsevier
Cancer therapies, including conventional chemotherapy, radiation, and molecularly targeted
agents, can lead to tumor eradication through a variety of mechanisms. In addition to their …
agents, can lead to tumor eradication through a variety of mechanisms. In addition to their …
Cytokine imbalance in schizophrenia. from research to clinic: potential implications for treatment
Cytokines are one of the most important components of the immune system. They
orchestrate the brain's response to infectious and other exogenous insults and are crucial …
orchestrate the brain's response to infectious and other exogenous insults and are crucial …