Epidemiology, staging, grading, and risk stratification of bladder cancer

M Colombel, M Soloway, H Akaza, A Böhle… - European urology …, 2008 - Elsevier
CONTEXT: Understanding the epidemiology and risk factors for non–muscle invasive
bladder cancer (NMIBC) can assist in the prevention and early detection of the disease …

Histologic grading of noninvasive papillary urothelial neoplasms

GT MacLennan, Z Kirkali, L Cheng - European urology, 2007 - Elsevier
OBJECTIVES: In 1998, a revised system of classifying noninvasive papillary urothelial
neoplasms of the urinary bladder was proposed and subsequently formally adopted by the …

Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behavior of bladder cancer

R Leão, D Lee, A Figueiredo… - … journal of cancer, 2019 - Wiley Online Library
In urothelial bladder cancer (UBC), risk stratification remains an important unmet need.
Limitless self‐renewal, governed by TERT expression and telomerase activation, is crucial …

Cancer heterogeneity and its biologic implications in the grading of urothelial carcinoma

L Cheng, RM Neumann, A Nehra, BE Spotts… - Cancer, 2000 - Wiley Online Library
BACKGROUND Urothelial carcinoma of the bladder often contains areas with different
histologic grades. The influence of cancer heterogeneity on grading and its relation to …

Controversial issues in Gleason and International Society of Urological Pathology (ISUP) prostate cancer grading: proposed recommendations for international …

JR Srigley, B Delahunt, H Samaratunga, A Billis… - Pathology, 2019 - Elsevier
Summary The Gleason Grading system has been used for over 50 years to prognosticate
and guide the treatment for patients with prostate cancer. At consensus conferences in 2005 …

[HTML][HTML] Relationship of cytokeratin 20 and CD44 protein expression with WHO/ISUP grade in pTa and pT1 papillary urothelial neoplasia

S Desai, SD Lim, RE Jimenez, T Chun, TE Keane… - Modern Pathology, 2000 - Elsevier
The aim of this study was to assess the relationship of immunoreactivity of cytokeratin 20
(CK20) and CD44 across the spectrum of urothelial neoplasia using the WHO/ISUP …

Discovery of novel bladder cancer biomarkers by comparative urine proteomics using iTRAQ technology

YT Chen, CL Chen, HW Chen, T Chung… - Journal of proteome …, 2010 - ACS Publications
A urine sample preparation workflow for the iTRAQ (isobaric tag for relative and absolute
quantitation) technique was established. The reproducibility of this platform was evaluated …

Long-term survival outcomes with intravesical docetaxel for recurrent nonmuscle invasive bladder cancer after previous bacillus Calmette-Guérin therapy

LMJ Barlow, JM McKiernan, MC Benson - The Journal of urology, 2013 - Elsevier
PURPOSE: Docetaxel is a safe agent for intravesical therapy. Adding monthly maintenance
treatments can extend response durability. We report our cumulative experience with …

Accuracy of urine cytology and the significance of an atypical category

F Brimo, RT Vollmer, B Case, A Aprikian… - American journal of …, 2009 - academic.oup.com
The “atypical urothelial cell” cytologic category is nonstandardized. We subclassify atypical
cases to “atypical, favor a reactive process” or “atypical, unclear if reactive or neoplastic.” We …

Micropapillary variant of urothelial carcinoma of the urinary bladder; a clinicopathological and immunohistochemical study

H Samaratunga, K Khoo - Histopathology, 2004 - Wiley Online Library
Aims: To investigate whether prognosis in micropapillary urothelial carcinoma is related to
the proportion of the micropapillary component (MPC), and to identify the …