BRAF inhibitors in thyroid cancer: clinical impact, mechanisms of resistance and future perspectives

F Crispo, T Notarangelo, M Pietrafesa, G Lettini… - Cancers, 2019 - mdpi.com
The Kirsten rat sarcoma viral oncogene homolog (RAS)/v-raf-1 murine leukemia viral
oncogene homolog 1 (RAF)/mitogen-activated protein kinase 1 (MAPK) signaling cascade is …

Osteopontin expression in thyroid cancer: deciphering EMT-related molecular mechanisms

BPPB Viana, AVP Gomes, ERP Gimba, LB Ferreira - Biomedicines, 2021 - mdpi.com
Thyroid cancer is the most common tumor arising from the endocrine system and generally
presents good prognosis. However, its aggressive subtypes are related to therapeutic …

Impact of BRAF V600E and TERT Promoter Mutations on Response to Therapy in Papillary Thyroid Cancer

T Trybek, A Walczyk, D Gąsior-Perczak, I Pałyga… - …, 2019 - academic.oup.com
In this study, we examined the relationship between coexisting BRAF V600E and TERT
promoter mutations in papillary thyroid cancer (PTC) and response to therapy. PTC cases …

The BRAFV600E mutation analysis and risk stratification in papillary thyroid carcinoma

RS Scheffel, AP Cristo, M Romitti… - … of endocrinology and …, 2020 - SciELO Brasil
Objective: Although the prognostic role of BRAFV600E mutation in papillary thyroid
carcinoma (PTC) is controversial, the American Thyroid Association (ATA) includes the …

Impact of BRAFV600E Mutation on Event-Free Survival in Patients with Papillary Thyroid Carcinoma: A Retrospective Study in a Romanian Population

A Nechifor-Boilă, A Zahan, C Bănescu, V Moldovan… - Cancers, 2023 - mdpi.com
Simple Summary Although papillary thyroid carcinoma (PTC) is generally a highly curable
disease, there is a small subgroup of PTC cases that behaves more aggressively, with high …

New biomarkers: prospect for diagnosis and monitoring of thyroid disease

MT Macvanin, ZM Gluvic, BL Zaric, M Essack… - Frontiers in …, 2023 - frontiersin.org
After the metabolic syndrome and its components, thyroid disorders represent the most
common endocrine disorders, with increasing prevalence in the last two decades. Thyroid …

The role of the size in thyroid cancer risk stratification

F Vianello, S Censi, S Watutantrige-Fernando… - Scientific Reports, 2021 - nature.com
Only a minority of cases of differentiated thyroid carcinoma (DTC) have a poor clinical
outcome. Clinical outcomes and molecular aspects were assessed in: 144 DTC≤ 40 mm …

Evaluation of the expression levels of BRAFV600E mRNA in primary tumors of thyroid cancer using an ultrasensitive mutation assay

TV Tran, KX Dang, QH Pham, UD Nguyen, NTT Trinh… - BMC cancer, 2020 - Springer
Abstract Background The BRAF V600E gene encodes for the mutant BRAF V600E protein,
which triggers downstream oncogenic signaling in thyroid cancer. Since most currently …

Elevated BANCR expression levels have different effects on papillary thyroid carcinoma progression depending on the presence of the BRAFV600E mutation

S Stojanović, S Šelemetjev, I Đorić, J Rončević… - European Journal of …, 2020 - Elsevier
Introduction The role of BRAF-activated non-protein coding RNA (BANCR) in papillary
thyroid carcinoma (PTC) is controversial, its clinical significance is unclear and no study has …

Programmed cell death 4 (PDCD4) as a novel prognostic marker for papillary thyroid carcinoma

F Galuppini, M Fassan, L Bertazza… - Cancer management …, 2019 - Taylor & Francis
Background The primary goal of papillary thyroid cancer (PTC) management was to stratify
patients at pre-and post-surgical level to identify the small proportion of cases with …