Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

[HTML][HTML] Role of structural and non-structural proteins and therapeutic targets of SARS-CoV-2 for COVID-19

R Yadav, JK Chaudhary, N Jain, PK Chaudhary… - Cells, 2021 - mdpi.com
Coronavirus belongs to the family of Coronaviridae, comprising single-stranded, positive-
sense RNA genome (+ ssRNA) of around 26 to 32 kilobases, and has been known to cause …

Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the
Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total …

COVID-19 vaccines: The status and perspectives in delivery points of view

JY Chung, MN Thone, YJ Kwon - Advanced drug delivery reviews, 2021 - Elsevier
Due to the high prevalence and long incubation periods often without symptoms, the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected millions of individuals …

COVID‐19: Virology, biology and novel laboratory diagnosis

M Mohamadian, H Chiti, A Shoghli… - The journal of gene …, 2021 - Wiley Online Library
Background At the end of December 2019, a novel coronavirus tentatively named SARS‐
CoV‐2 in Wuhan, a central city in China, was announced by the World Health Organization …

Epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of COVID-19: a review of current evidence

S Rahman, MTV Montero, K Rowe… - Expert review of …, 2021 - Taylor & Francis
Introduction The COVID-19 pandemic has created a public health crisis, infected millions of
people, and caused a significant number of deaths. SARS-CoV-2 transmits from person to …

COVID-19 vaccine frontrunners and their nanotechnology design

YH Chung, V Beiss, SN Fiering, NF Steinmetz - ACS nano, 2020 - ACS Publications
Humanity is experiencing a catastrophic pandemic. SARS-CoV-2 has spread globally to
cause significant morbidity and mortality, and there still remain unknowns about the biology …

Diagnostics for SARS-CoV-2 detection: A comprehensive review of the FDA-EUA COVID-19 testing landscape

N Ravi, DL Cortade, E Ng, SX Wang - Biosensors and bioelectronics, 2020 - Elsevier
The rapidly spreading outbreak of COVID-19 disease is caused by the SARS-CoV-2 virus,
first reported in December 2019 in Wuhan, China. As of June 17, 2020, this virus has …

Nucleic acid delivery for therapeutic applications

A Gupta, JL Andresen, RS Manan, R Langer - Advanced Drug Delivery …, 2021 - Elsevier
Recent medical advances have exploited the ability to address a given disease at the
underlying level of transcription and translation. These treatment paradigms utilize nucleic …

Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines

A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
Coronavirus disease 2019 (COVID-19) has swept the world, unlike any other pandemic in
the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; …