Abstract Purpose of Review Effective acute pain management has evolved considerably in
recent years and is a primary area of focus in attempts to defend against the opioid …

The rapid spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
has led to a global pandemic. The 2019 coronavirus disease (COVID-19) presents with a …

Clonidine, an alpha-2 agonist, is most widely known and used as an antihypertensive agent.
Although most of the focus on clonidine is on its ability to reduce blood pressure, it also has …

BACKGROUND Delirium is common in the ICU, with incidence rates reported to be upwards
of 70%. Due to the significant morbidity and mortality associated with delirium, it is …

General anesthesia in animal experiments is an ethical must and is required for all the
procedures that are likely to cause more than slight or momentary pain. As anesthetics are …

The alpha2-adrenergic receptor agonist Dexmedetomidine (Dex) is a sedative medication
used by anesthesiologists. Dex protects the heart against ischemia-reperfusion (IR) and can …

Neuropathic pain can arise from disease or damage to the nervous system. The most
common symptoms of neuropathic pain include spontaneous pain, allodynia, and …

The effects of dexmedetomidine in adults undergoing cardiac surgery are inconsistent. We
conducted a systematic review and meta‐analysis to analyse the effects of peri‐operative …

Background Dexmedetomidine (DEX), is a highly selective alpha2 adrenoceptor (α2-AR)
agonist, successfully used in various procedures including flexible bronchoscopy …

Background: Dexmedetomidine has been shown to have an analgesic effect. However, no
consensus was reached in previous studies. Methods: Electronic databases such as …