[HTML][HTML] Роль MAP-киназных механизмов в регуляции клеточного роста (обзор литературы)

ИА Шурыгина, МГ Шурыгин, НВ Зеленин… - Байкальский …, 2009 - cyberleninka.ru
В статье обобщены современные представления о роли МАР-киназных механизмов в
регуляции клеточного роста и дифференцировки. Особое внимание уделено роли …

[HTML][HTML] Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

SF Tan, W Dunton, X Liu, TE Fox, SAF Morad… - Journal of lipid …, 2019 - ASBMB
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. More than half
of older AML patients fail to respond to cytotoxic chemotherapy, and most responders …

Regulation of drug transporters by microRNA and implications in disease treatment

YJ Chae, JE Chang, MK Lee, J Lim, KH Shin… - Journal of …, 2022 - Springer
Background Transporters play crucial roles in the pharmacokinetics of drugs, consequently
influencing efficacy and toxicity by unexpectedly altering drug concentrations. Epigenetic …

MDR1 mRNA expression and MDR1 gene variants as predictors of response to chemotherapy in patients with acute myeloid leukaemia: a meta-analysis

C Doxani, M Voulgarelis, E Zintzaras - Biomarkers, 2013 - Taylor & Francis
Data from 30 pharmacogenomic studies that investigated MDR1 mRNA expression or gene
variants (C3435T, G2677TA, C1236T) and response to therapy in acute myeloid leukaemia …

P-glycoprotein mediated multidrug resistance and its implications for pathology

CM Trambas, HK Muller, GM Woods - Pathology, 1997 - Taylor & Francis
The discovery of P-glycoprotein has revealed a fundamental mechanism by which cancer
cells evade chemotherapy and this principle has proven relevant to general cellular defence …

Multi-drug resistance (MDR1) gene expression in de novo acute leukemia cells: correlations with CD surface markers and treatment outcome

EZ Jiang, YJ Chang, JW Lee, WK Lee… - Journal of Korean …, 1998 - synapse.koreamed.org
One important mechanism of drug resistance in acute leukemia is the overexpression of the
multi-drug resistance (MDR1) gene that encodes a 170-kDa membrane protein called P …

[HTML][HTML] Новые методы биотерапии рака пищеварительного тракта. Патофизиологические и клинические аспекты (обзор)

МЮ Хлусова, СА Антипов, ИА Хлусов… - Байкальский …, 2009 - cyberleninka.ru
Наряду с методами ад птивной клеточной терапии и вакцинотерапии, активно
разрабатываемыми в последние 20-25 лет, в настоящее время внимание …