Spatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine

LX Chu, WJ Wang, XP Gu, P Wu, C Gao… - Military Medical …, 2024 - Springer
Aging and regeneration represent complex biological phenomena that have long captivated
the scientific community. To fully comprehend these processes, it is essential to investigate …

Advancements in neuroregenerative and neuroprotective therapies for traumatic spinal cord injury

G Fischer, L Bättig, MN Stienen, A Curt… - Frontiers in …, 2024 - frontiersin.org
Traumatic spinal cord injuries (SCIs) continue to be a major healthcare concern, with a rising
prevalence worldwide. In response to this growing medical challenge, considerable …

Current multi-scale biomaterials for tissue regeneration following spinal cord injury

Y ang Zhang, Z huan Wu, J feng Wu, T dong Li… - Neurochemistry …, 2024 - Elsevier
Spinal cord injury (SCI) may cause loss of motor and sensory function, autonomic
dysfunction, and thus disrupt the quality of life of patients, leading to severe disability and …

Platelet-rich plasma-derived exosomes promote blood-spinal cord barrier repair and attenuate neuroinflammation after spinal cord injury

X Nie, Y Liu, T Yuan, T Yu, Z Yun, W Xue, T Yu… - Journal of …, 2024 - Springer
Spinal cord injury (SCI) compromises the blood-spinal cord barrier (BSCB) and induces
neuroinflammation, potentially exacerbating neuronal damage. This underscores the …

Hydrogel-based therapeutic strategies for spinal cord injury repair: Recent advances and future prospects

N Li, J He - International Journal of Biological Macromolecules, 2024 - Elsevier
Spinal cord injury (SCI) is a debilitating condition that can result in significant functional
impairment and loss of quality of life. There is a growing interest in developing new …

MicroRNA-9 promotes axon regeneration of mauthner-cell in zebrafish via her6/ calcium activity pathway

Y Shen, X Chen, Z Song, H Yao, A Han… - Cellular and Molecular …, 2024 - Springer
MicroRNA (miRNA), functioning as a post-transcriptional regulatory element, plays a
significant role in numerous regulatory mechanisms and serves as a crucial intrinsic factor …

[HTML][HTML] New strategy to treat spinal cord injury: Nafamostat mesilate suppressed NLRP3-mediated pyroptosis during acute phase

Y Lou, Z Li, H Zheng, Z Yuan, W Li, J Zhang… - International …, 2024 - Elsevier
Spinal cord injury (SCI) is a devastating condition for which effective clinical treatment is
currently lacking. During the acute phase of SCI, myriad pathological changes give rise to …

[HTML][HTML] A biomimic anti-neuroinflammatory nanoplatform for active neutrophil extracellular traps targeting and spinal cord injury therapy

C Tang, Y Jin, M Wu, F Jia, X Lu, J Li, J Wu, S Zhu… - Materials Today Bio, 2024 - Elsevier
Traumatic spinal cord injury (SCI) always leads to severe neurological deficits and
permanent damage. Neuroinflammation is a vital process of SCI and have become a …

Influential factors on stem cell therapy success in canine model of spinal cord Injury: A systematic review and meta-analysis

A Dadvand, A Yavari, A Teimourpour… - Brain Research, 2024 - Elsevier
Spinal cord injury (SCI) is a serious medical condition. The search for an effective cure
remains a persistent challenge. Current treatments, unfortunately, are unable to sufficiently …

Neutrophil membrane-coated multifunctional biomimetic nanoparticles for spinal cord injuries

H Zhu, F Cai, Z Li, L Zhang, X Zhou, J Yao… - Journal of …, 2024 - Taylor & Francis
Spinal cord injury (SCI) is one of the most complex diseases. After SCI, severe secondary
injuries can cause intense inflammatory storms and oxidative stress responses, leading to …