The fact that not all individuals exposed to the same environmental risk factors develop
obesity supports the hypothesis of the existence of underlying genetic and epigenetic …

Regulatory T (Treg) cells are a developmentally and functionally distinct T cell
subpopulation that is engaged in sustaining immunological self-tolerance and homeostasis …

T cell help to B cells is a fundamental aspect of adaptive immunity and the generation of
immunological memory. Follicular helper CD4 T (TFH) cells are the specialized providers of …

CD4+ T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although
the precise mechanisms that control their development are undefined. Here we present data …

The differentiation of naive CD4+ T cells into lineages with distinct effector functions has
been considered to be an irreversible event. T helper type 1 (Th1) cells stably express IFN-γ …

The memory T cell pool functions as a dynamic repository of antigen-experienced T
lymphocytes that accumulate over the lifetime of the individual. Recent studies indicate that …

Abstract Interferon‐γ (IFN‐γ) is crucial for immunity against intracellular pathogens and for
tumor control. However, aberrant IFN‐γ expression has been associated with a number of …

The NFAT family of transcription factors encompasses five proteins evolutionarily related to
the Rel/NFκB family (Chytil and Verdine 1996; Graef et al. 2001b). The primordial family …

Since the discovery of T helper type 1 and type 2 effector T cell subsets 20 years ago,
inducible regulatory T cells and interleukin 17 (IL-17)-producing T helper cells have been …

Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a
decade ago, the NFAT family of transcription factors has grown to include five members. It …