The ventral tegmental area (VTA) is well known for regulating reward consumption, learning,
memory, and addiction behaviors through mediating dopamine (DA) release in downstream …

Objective To investigate change in mental health after smoking cessation compared with
continuing to smoke. Design Systematic review and meta-analysis of observational studies …

Background There is a common perception that smoking generally helps people to manage
stress, and may be a form of'selfmedication'in people with mental health conditions …

With the advent of nicotine replacement therapy, the consumption of the nicotine is on the
rise. Nicotine is considered to be a safer alternative of tobacco. The IARC monograph has …

This review gives an account of the cigarette as a highly efficient nicotine delivery system. It
explains how nicotine induces pleasure, reduces stress and anxiety, and causes addiction …

Background Cigarette smoking has been linked with both increased and decreased risk for
Alzheimer's disease (AD). This is relevant for the US military because the prevalence of …

The classical studies of nicotine by Langley at the turn of the 20th century introduced the
concept of a “receptive substance,” from which the idea of a “receptor” came to light …

Nicotine is a highly addictive drug found in tobacco that drives its continued use despite the
harmful consequences. The initiation of nicotine abuse involves the mesolimbic dopamine …

Nicotine sustains tobacco addiction, a major cause of disability and premature death.
Nicotine binds to nicotinic cholinergic receptors, facilitating neurotransmitter release and …

Nicotinic acetylcholine receptors (nAChRs) belong to the “Cys-loop” superfamily of ligand-
gated ion channels that includes GABA A, glycine, and serotonin (5-HT 3) receptors. There …