As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

Recent evidence clearly shows that cells respond to various physical cues in their
environments, guiding many cellular processes and tissue morphogenesis, pathology, and …

The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

Yes-associated protein (YAP) is a key mechanotransduction protein in diverse physiological
and pathological processes; however, a ubiquitous YAP activity regulatory mechanism in …

Cells have evolved multiple mechanisms to apprehend and adapt finely to their
environment. Here we report a new cellular ability, which we term “curvotaxis” that enables …

Targeting the delivery of therapeutics specifically to diseased tissue enhances their efficacy
and decreases their side effects. Here we show that mesenchymal stromal cells with their …

Cancer metastasis, ie, the spreading of tumor cells from the primary tumor to distant organs,
is responsible for the vast majority of cancer deaths. In the process, cancer cells migrate …

From embryonic development to cancer metastasis, cell migration plays a central role in
health and disease. It is increasingly becoming apparent that cells migrating in three …

The capability to directly interrogate intracellular structures inside a single cell for
measurement and manipulation is important for understanding subcellular and suborganelle …