Highlights•Explores the mechanism of glycation and AGE production.•Describes the
aberrantly activated pathways through AGE-RAGE interaction.•Emphasizes the important of …

Bone metabolism is closely related to oxidative stress. As one of the core regulatory factors
of oxidative stress, NRF2 itself and its regulation of oxidative stress are both involved in …

Osteoporosis is a prevalent bone disorder characterized by bone mass reduction and
deterioration of bone microarchitecture leading to bone fragility and fracture risk. In recent …

Excessive oxidative stress will cause significant injury to osteoblasts, serving as one major
pathological mechanism of osteoporosis. Neuroligin-3 (NLGN3) is a postsynaptic cell …

Increasing bone resorption followed by decreasing bone mineralization are hallmarks of
bone degeneration, which mostly occurs in the elderly population and post-menopausal …

An ultra-large structure-based virtual screening has discovered iKeap1 as a direct Keap1
inhibitor that can efficiently activate Nrf2 signaling. We here tested its potential effect against …

The development of progressive osteopenia and osteoporosis (OP) is due to the imbalance
between bone resorption and bone formation, determining a lower bone resistance, major …

Highlights•The extract of PMR exhibited excellent pharmacological effect on the DSS
induced acute ulcerative colitis in mice.•TSG is the major bioactive component isolated from …

Docosahexaenoic acid (DHA) is an omega‑3 polyunsaturated fatty acid, derived mainly from
fish oil. It is well known that DHA is present in high concentrations in nervous tissue and …

Background: Alzheimer's disease (AD) is the most common neurodegenerative condition
worldwide, with amyloid ß (Aβ) fibrils presenting as its main pathological feature. This study …