Pyroptosis is a kind of programmed cell death closely related to inflammation. The pathways
that mediate pyroptosis can be divided into the Caspase-1-dependent canonical pathway …

Stem cell therapies have shown promising therapeutic effects in restoring damaged tissue
and promoting functional repair in a wide range of human diseases. Generations of insulin …

Aim Pyroptosis and inflammaging have been newly identified to be involved in diabetic
periodontitis. This study aimed to elucidate whether macrophage pyroptosis plays a role in …

Phthalates (PAEs) are considered endocrine-disrupting chemicals (EDCs), a series of
compounds able to disrupt the normal regulation of the human endocrine-system. In the …

Diabetic cardiomyopathy (DCM) is an important complication leading to the death of patients
with diabetes, but there is no effective strategy for clinical treatments. Fufang Zhenzhu …

Cytomegalovirus (CMV) is a widely prevalent herpesvirus that reaches seroprevalence rates
of up to 95% in several parts of the world. The majority of CMV infections are asymptomatic …

Background: Acute myocardial infarction (AMI) is a fatal disease that results in high morbidity
and mortality. It has been reported that AMI is associated with immune cell infiltration …

Apoptosis plays particularly important roles in tumorigenesis through various mechanisms.
Apoptosis can be initiated by both extrinsic and intrinsic signals centered in and coming from …

Background Stroke is the second leading cause of death and the third leading cause of
disability worldwide, with ischemic stroke (IS) being the most prevalent. A substantial …

Imeglimin and metformin act in metabolic organs, including β-cells, via different
mechanisms. In the present study, we investigated the impacts of imeglimin, metformin, or …