To the cell biology student of the 1980s, it may come as a surprise to learn that until the late
1950s, the existence of the Golgi apparatus as a bona fide cell organelle was seriously …

Insulin secretion plays a pivotal role in glucose homeostasis. An increased rate of insulin
release is the only efficient means by which the organism can rapidly decrease circulating …

Insulin is produced from an inactive precursor, proinsulin, through initial endoproteolytic
cleavage at sites marked by pairs of basic amino-acid residues1, 2. We report here that …

SUMMARY 1 After an outline description of pancreatic structure and function, and a more
detailed account of acinar cell morphology, this review traces the pathway of amino acids as …

Homeostatic regulation of metabolic fuels involves the generally opposing actions of insulin
and glucagon. As most agents simultaneously affect secretion of both hormones, this review …

The concentrations of Zn2+, Ca2+, Mg2+, Pi and adenine nucleotides were determined in
insulin-secretory granules prepared from a transplantable rat insulinoma. Differential and …

The immediate and direct regulation of insulin release by circulating nutrients, especially
glucose, is thought to be mediated in the pancreatic B-cell by a sequence of metabolic, ionic …

The insulin secretory granule of the pancreatic B cell is a complex intracellular organelle
comprised of a many proteins with different catalytic activities and messenger functions. With …

The membrane potential (ΔΨ) and the pH gradient (ΔpH) across the membrane of the
insulin-secretory granule were determined in studies in vitro from the uptake of the permeant …

Accumulation and subcellular localization of dopamine (DA) in pancreatic B-cells and its
effects on insulin secretion were investigated in mice following a single injection of L-3, 4 …