Functional imaging of the lungs with gas agents
This review focuses on the state‐of‐the‐art of the three major classes of gas contrast agents
used in magnetic resonance imaging (MRI)—hyperpolarized (HP) gas, molecular oxygen …
used in magnetic resonance imaging (MRI)—hyperpolarized (HP) gas, molecular oxygen …
The role of hyperpolarized 129xenon in MR imaging of pulmonary function
In the last two decades, functional imaging of the lungs using hyperpolarized noble gases
has entered the clinical stage. Both helium (3 He) and xenon (129 Xe) gas have been …
has entered the clinical stage. Both helium (3 He) and xenon (129 Xe) gas have been …
The gravitational distribution of ventilation-perfusion ratio is more uniform in prone than supine posture in the normal human lung
AC Henderson, RC Sá, RJ Theilmann… - Journal of applied …, 2013 - journals.physiology.org
The gravitational gradient of intrapleural pressure is suggested to be less in prone posture
than supine. Thus the gravitational distribution of ventilation is expected to be more uniform …
than supine. Thus the gravitational distribution of ventilation is expected to be more uniform …
Using hyperpolarized 129Xe MRI to quantify the pulmonary ventilation distribution
Rationale and Objectives Ventilation heterogeneity is impossible to detect with spirometry.
Alternatively, pulmonary ventilation can be imaged three-dimensionally using inhaled 129 …
Alternatively, pulmonary ventilation can be imaged three-dimensionally using inhaled 129 …
Free-breathing Dynamic 19F Gas MR Imaging for Mapping of Regional Lung Ventilation in Patients with COPD
M Gutberlet, TF Kaireit, A Voskrebenzev, F Lasch… - Radiology, 2018 - pubs.rsna.org
Purpose To quantify regional lung ventilation in patients with chronic obstructive pulmonary
disease (COPD) by using free-breathing dynamic fluorinated (fluorine 19 [19F]) gas …
disease (COPD) by using free-breathing dynamic fluorinated (fluorine 19 [19F]) gas …
Quantitative imaging metrics for the assessment of pulmonary pathophysiology: an official American Thoracic Society and Fleischner Society joint workshop report
Multiple thoracic imaging modalities have been developed to link structure to function in the
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …
diagnosis and monitoring of lung disease. Volumetric computed tomography (CT) renders …
Quantification of regional fractional ventilation in human subjects by measurement of hyperpolarized 3He washout with 2D and 3D MRI
FC Horn, MH Deppe, H Marshall… - Journal of applied …, 2014 - journals.physiology.org
Multiple-breath washout hyperpolarized 3He MRI was used to calculate regional parametric
images of fractional ventilation (r) as the ratio of fresh gas entering a volume unit to the total …
images of fractional ventilation (r) as the ratio of fresh gas entering a volume unit to the total …
A computational model of the topographic distribution of ventilation in healthy human lungs
The topographic distribution of ventilation in the lungs is determined by the interaction of
several factors, including lung shape, airway tree geometry, posture, and tissue deformation …
several factors, including lung shape, airway tree geometry, posture, and tissue deformation …
Free‐breathing quantification of regional ventilation derived by phase‐resolved functional lung (PREFUL) MRI
F Klimeš, A Voskrebenzev, M Gutberlet… - NMR in …, 2019 - Wiley Online Library
Purpose To test the feasibility of regional fully quantitative ventilation measurement in free
breathing derived by phase‐resolved functional lung (PREFUL) MRI in the supine and …
breathing derived by phase‐resolved functional lung (PREFUL) MRI in the supine and …
Proton MRI of the lung: how to tame scarce protons and fast signal decay
A Voskrebenzev… - Journal of Magnetic …, 2021 - Wiley Online Library
Pulmonary proton MRI techniques offer the unique possibility of assessing lung function and
structure without the requirement for hyperpolarization or dedicated hardware, which is …
structure without the requirement for hyperpolarization or dedicated hardware, which is …