Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …

Adolescence is a time of major plasticity of brain systems that regulate motivated behavior
and cognition, and is also the age of peak onset of nicotine use. Although there has been a …

Substance use disorders occur commonly in patients with schizophrenia and dramatically
worsen their overall clinical course. While the exact mechanisms contributing to substance …

Over the past decade, many studies have indicated that adolescence is a critical period of
brain development and maturation. The refinement and maturation of the central nervous …

The synthetic cathinones are derived from the naturally occurring drug cathinone found in
the khat plant (Catha edulis) and have chemical structures and neurochemical …

Concurrent use of tobacco and alcohol or psychostimulants represents a major public health
concern, with use of one substance influencing consumption of the other. Co-abuse of these …

Drug use and abuse are complex issues in that the basis of each may involve different
determinants and consequences, and the transition from one to the other may be equally …

Despite widespread cannabis use in humans, few rodent models exist demonstrating
significant Δ 9-tetrahydrocannabinol (THC) self-administration, possibly due to THC's co …

Rationale The majority of synthetic cathinone research has used only male subjects, and as
a result there are few studies assessing the impact of biological sex on their effects …

Tobacco smoking is recognized as a life-threatening risk factor worldwide. Initiation of
smoking primarily occurs during adolescence which is a critical developmental phase …