Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells

GM Bertolino, M Maumus, C Jorgensen… - Nature Reviews …, 2023 - nature.com
The incidence of rheumatic diseases such as rheumatoid arthritis and osteoarthritis and
injuries to articular cartilage that lead to osteochondral defects is predicted to rise as a result …

The emerging role of exosomes in innate immunity, diagnosis and therapy

P Gangadaran, H Madhyastha, R Madhyastha… - Frontiers in …, 2023 - frontiersin.org
Exosomes, which are nano-sized transport bio-vehicles, play a pivotal role in maintaining
homeostasis by exchanging genetic or metabolic information between different cells …

Integrated printed BDNF-stimulated HUCMSCs-derived exosomes/collagen/chitosan biological scaffolds with 3D printing technology promoted the remodelling of …

X Liu, J Zhang, X Cheng, P Liu, Q Feng… - Regenerative …, 2023 - academic.oup.com
The restoration of nerve dysfunction after traumatic brain injury (TBI) faces huge challenges
due to the limited self-regenerative abilities of nerve tissues. In situ inductive recovery can …

Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis

Z Zhang, S Zhao, Z Sun, C Zhai, J Xia, C Wen… - Cellular & Molecular …, 2023 - Springer
Osteoarthritis (OA), a common joint disorder with articular cartilage degradation as the main
pathological change, is the major source of pain and disability worldwide. Despite current …

Exosomes derived from mesenchymal stem cells rescue cartilage injury in osteoarthritis through Ferroptosis by GOT1/CCR2 expression

S Peng, C Sun, C Lai, L Zhang - International Immunopharmacology, 2023 - Elsevier
Osteoarthritis is a prevalent joint disease that significantly affects the daily life of the elderly
and is one of the primary causes of disability in this population. This study aims to evaluate …

Osteoarthritis as an umbrella term for different subsets of humans undergoing joint degeneration: The need to address the differences to develop effective …

DA Hart - International Journal of Molecular Sciences, 2022 - mdpi.com
Osteoarthritis (OA) of joints such as the knee and hip are very prevalent, and the number of
individuals affected is expected to continue to rise. Currently, conservative treatments after …

[HTML][HTML] Innovative therapeutic strategies for cardiovascular disease

K Maiese - EXCLI journal, 2023 - ncbi.nlm.nih.gov
As a significant non-communicable disease, cardiovascular disease is the leading cause of
death for both men and women, comprises almost twenty percent of deaths in most racial …

Combinatorial effect of mesenchymal stem cells and extracellular vesicles in a hydrogel on cartilage regeneration

WJ Cho, J Ahn, M Lee, H Choi, S Park, KY Cha… - Tissue Engineering and …, 2023 - Springer
Abstract Background: Mesenchymal stem cells (MSCs) are used for tissue regeneration due
to their wide differentiation capacity and anti-inflammatory effects. Extracellular vesicles …

[HTML][HTML] Current status of catabolic, anabolic and inflammatory biomarkers associated with structural and symptomatic changes in the chronic phase of post-traumatic …

O O'Sullivan, P Ladlow, K Steiner, C Hillman… - … and Cartilage Open, 2023 - Elsevier
Post-traumatic OA (PTOA) can occur within 5 years after a significant injury and is a valuable
paradigm for identifying biomarkers. This systematic review aims to summarise published …

Strategy insight: Mechanical properties of biomaterials' influence on hydrogel-mesenchymal stromal cell combination for osteoarthritis therapy

H Ying, C Shen, R Pan, X Li, Y Chen - Frontiers in Pharmacology, 2023 - frontiersin.org
Osteoarthritis (OA) is a kind of degenerative joint disease usually found in older adults and
those who have received meniscal surgery, bringing great suffering to a number of patients …