Myocardial ischemia-reperfusion injury is an important cause of impaired heart function in
the early postoperative period subsequent to cardiac surgery. Reactive oxygen species …

There is substantial evidence that oxidative stress participates in the pathophysiology of
cardiovascular disease. Biochemical, molecular and pharmacological studies further …

Xanthine oxidoreductase (XOR) is a complex molybdoflavoenzyme, present in milk and
many other tissues, which has been studied for over 100 years. While it is generally …

Free radical oxidative stress has been implicated in the pathogenesis of a variety of human
diseases. Natural antioxidant defences have been found to be defective in many of the same …

While timely reperfusion of acute ischemic myocardium is essential for myocardial salvage,
reperfusion results in a unique form of myocardial damage. Functional alterations occur …

Background—Serum uric acid (UA) could be a valid prognostic marker and useful for
metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF) …

Oxidative stress in the myocardium may play an important role in the pathogenesis of
congestive heart failure (HF). However, the cellular sources and mechanisms for the …

Previous in vitro studies have shown that isolated mitochondria can generate oxygen
radicals. However, whether a similar phenomenon can also occur in intact organs is …

Decreased tissue oxygen tension is a component of many diseases. Although hypoxia can
be secondary to a low inspired P0 2 or a variety of lung disorders, the commonest cause is …

In the current issue of Circulation, Anker and colleagues1 report that elevated levels of uric
acid (UA) predict mortality and the need for heart transplantation in patients with congestive …