Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds
HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …
The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …
Therapeutic potential of luteolin on cancer
M Çetinkaya, Y Baran - Vaccines, 2023 - mdpi.com
Cancer is a global concern, as the rate of incidence is increasing each year. The challenges
related to the current chemotherapy drugs, such as the concerns related to toxicity, turn to …
related to the current chemotherapy drugs, such as the concerns related to toxicity, turn to …
Anticancer activity of the plant flavonoid luteolin against preclinical models of various cancers and insights on different signalling mechanisms modulated
Various signaling mechanisms contribute significantly to the development of multiple
cancers. Small molecules with the potential of influencing a wide variety of molecular targets …
cancers. Small molecules with the potential of influencing a wide variety of molecular targets …
Natural plants compounds as modulators of epithelial-to-mesenchymal transition
L Avila-Carrasco, P Majano… - Frontiers in …, 2019 - frontiersin.org
Epithelial-to-mesenchymal transition (EMT) is a self-regulated physiological process
required for tissue repair that, in non-controled conditions may lead to fibrosis …
required for tissue repair that, in non-controled conditions may lead to fibrosis …
Luteolin, a potent anticancer compound: from chemistry to cellular interactions and synergetic perspectives
Simple Summary Common flavonoid luteolin 3′, 4′, 5, 7-tetrahydroxyflavone has
immense potential to be utilized as a chemopreventive dietary molecule. According to …
immense potential to be utilized as a chemopreventive dietary molecule. According to …
Enzymatic metabolism of flavonoids by gut microbiota and its impact on gastrointestinal cancer
RK Al-Ishaq, A Liskova, P Kubatka, D Büsselberg - Cancers, 2021 - mdpi.com
Simple Summary Flavonoid's consumption is reported to impact GI cancer progression
positively. As 90% of flavonoids consumed, undergo metabolism and conversion by the …
positively. As 90% of flavonoids consumed, undergo metabolism and conversion by the …
Small molecule inhibitors of epithelial‐mesenchymal transition for the treatment of cancer and fibrosis
YL Feng, DQ Chen, ND Vaziri, Y Guo… - Medicinal research …, 2020 - Wiley Online Library
Tissue fibrosis and cancer both lead to high morbidity and mortality worldwide; thus,
effective therapeutic strategies are urgently needed. Because drug resistance has been …
effective therapeutic strategies are urgently needed. Because drug resistance has been …
Multi-faceted role of luteolin in cancer metastasis: EMT, angiogenesis, ECM degradation and apoptosis
MT Rocchetti, F Bellanti, M Zadorozhna… - International Journal of …, 2023 - mdpi.com
Luteolin (3′, 4′, 5, 7-tetrahydroxyflavone), a member of the flavonoid family derived from
plants and fruits, shows a wide range of biomedical applications. In fact, due to its anti …
plants and fruits, shows a wide range of biomedical applications. In fact, due to its anti …
[HTML][HTML] Luteolin inhibits subretinal fibrosis and epithelial-mesenchymal transition in laser-induced mouse model via suppression of Smad2/3 and YAP signaling
C Zhang, Y Zhang, X Hu, Z Zhao, Z Chen, X Wang… - Phytomedicine, 2023 - Elsevier
Background Subretinal fibrosis (SF) accounts for vision loss in patients with neovascular age-
related macular degeneration (nAMD) even treated with adequate intravitreal injection of …
related macular degeneration (nAMD) even treated with adequate intravitreal injection of …