Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges

CY Loh, JY Chai, TF Tang, WF Wong, G Sethi… - Cells, 2019 - mdpi.com
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …

Therapeutic potential of luteolin on cancer

M Çetinkaya, Y Baran - Vaccines, 2023 - mdpi.com
Cancer is a global concern, as the rate of incidence is increasing each year. The challenges
related to the current chemotherapy drugs, such as the concerns related to toxicity, turn to …

Anticancer activity of the plant flavonoid luteolin against preclinical models of various cancers and insights on different signalling mechanisms modulated

SA Ganai, FA Sheikh, ZA Baba, MA Mir… - Phytotherapy …, 2021 - Wiley Online Library
Various signaling mechanisms contribute significantly to the development of multiple
cancers. Small molecules with the potential of influencing a wide variety of molecular targets …

Natural plants compounds as modulators of epithelial-to-mesenchymal transition

L Avila-Carrasco, P Majano… - Frontiers in …, 2019 - frontiersin.org
Epithelial-to-mesenchymal transition (EMT) is a self-regulated physiological process
required for tissue repair that, in non-controled conditions may lead to fibrosis …

Luteolin, a potent anticancer compound: from chemistry to cellular interactions and synergetic perspectives

H Singh Tuli, P Rath, A Chauhan, K Sak, D Aggarwal… - Cancers, 2022 - mdpi.com
Simple Summary Common flavonoid luteolin 3′, 4′, 5, 7-tetrahydroxyflavone has
immense potential to be utilized as a chemopreventive dietary molecule. According to …

Enzymatic metabolism of flavonoids by gut microbiota and its impact on gastrointestinal cancer

RK Al-Ishaq, A Liskova, P Kubatka, D Büsselberg - Cancers, 2021 - mdpi.com
Simple Summary Flavonoid's consumption is reported to impact GI cancer progression
positively. As 90% of flavonoids consumed, undergo metabolism and conversion by the …

Small molecule inhibitors of epithelial‐mesenchymal transition for the treatment of cancer and fibrosis

YL Feng, DQ Chen, ND Vaziri, Y Guo… - Medicinal research …, 2020 - Wiley Online Library
Tissue fibrosis and cancer both lead to high morbidity and mortality worldwide; thus,
effective therapeutic strategies are urgently needed. Because drug resistance has been …

Multi-faceted role of luteolin in cancer metastasis: EMT, angiogenesis, ECM degradation and apoptosis

MT Rocchetti, F Bellanti, M Zadorozhna… - International Journal of …, 2023 - mdpi.com
Luteolin (3′, 4′, 5, 7-tetrahydroxyflavone), a member of the flavonoid family derived from
plants and fruits, shows a wide range of biomedical applications. In fact, due to its anti …

[HTML][HTML] Luteolin inhibits subretinal fibrosis and epithelial-mesenchymal transition in laser-induced mouse model via suppression of Smad2/3 and YAP signaling

C Zhang, Y Zhang, X Hu, Z Zhao, Z Chen, X Wang… - Phytomedicine, 2023 - Elsevier
Background Subretinal fibrosis (SF) accounts for vision loss in patients with neovascular age-
related macular degeneration (nAMD) even treated with adequate intravitreal injection of …