Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Angiogenesis after acute myocardial infarction

X Wu, MR Reboll, M Korf-Klingebiel… - Cardiovascular …, 2021 - academic.oup.com
Acute myocardial infarction (MI) inflicts massive injury to the coronary microcirculation
leading to vascular disintegration and capillary rarefication in the infarct region. Tissue …

Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

YK Tham, BC Bernardo, JYY Ooi, KL Weeks… - Archives of …, 2015 - Springer
The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

An injectable conductive hydrogel encapsulating plasmid DNA-eNOs and ADSCs for treating myocardial infarction

W Wang, B Tan, J Chen, R Bao, X Zhang, S Liang… - Biomaterials, 2018 - Elsevier
Myocardial infarction (MI) leads to the mass death of cardiomyocytes accompanying with the
unfavorable alternation of microenvironment, a fibrosis scar deprived of electrical …

A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo

KA Hajj, JR Melamed, N Chaudhary, NG Lamson… - Nano …, 2020 - ACS Publications
The clinical translation of messengerRNA (mRNA) drugs has been slowed by a shortage of
delivery vehicles that potently and safely shuttle mRNA into target cells. Here, we describe …

Recent development in therapeutic cardiac patches

X Mei, K Cheng - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
For the past decades, heart diseases remain the leading cause of death worldwide. In the
adult mammalian heart, damaged cardiomyocytes will be replaced by non-contractile fibrotic …

Towards comprehensive cardiac repair and regeneration after myocardial infarction: Aspects to consider and proteins to deliver

HK Awada, MP Hwang, Y Wang - Biomaterials, 2016 - Elsevier
Ischemic heart disease is a leading cause of death worldwide. After the onset of myocardial
infarction, many pathological changes take place and progress the disease towards heart …

Cell-based and selected cell-free therapies for myocardial infarction: how do they compare to the current treatment options?

M Csöbönyeiová, N Beerová, M Klein… - International Journal of …, 2022 - mdpi.com
Because of cardiomyocyte death or dysfunction frequently caused by myocardial infarction
(MI), heart failure is a leading cause of morbidity and mortality in modern society …

[HTML][HTML] Cardiac regeneration using growth factors: advances and challenges

JS Rebouças, NS Santos-Magalhães… - Arquivos brasileiros de …, 2016 - SciELO Brasil
Myocardial infarction is the most significant manifestation of ischemic heart disease and is
associated with high morbidity and mortality. Novel strategies targeting at regenerating the …

Recent advances in micro/nanoscale biomedical implants

A Arsiwala, P Desai, V Patravale - Journal of Controlled Release, 2014 - Elsevier
The medical device industry is growing at a very fast pace and has recorded great research
activity over the past decade. The interdisciplinary nature of this field has made it possible …