Molecular biomarkers that interact with the vascular and immune compartments play an
important role in the progression of solid malignancies. CD105, which is a component of the …

Simple Summary The modulation of tumor blood vessels is a great opportunity for improving
cancer therapies. Understanding the cellular and molecular players that regulate the biology …

Objectives The interaction between tumor cells and stroma is critical in tumorigenesis, tumor
neo–angiogenesis and cancer progression. The aims of this study were to:(i) evaluate the …

Introduction: Bone metastasis is one of the causes that mainly decrease survival in patients
with advanced breast cancer. Therefore, it is essential to find prognostic markers for the …

Background: Although doxorubicin (DXR) is one of the most used anticancer drugs, it can
cause life-threatening renal damage. There has been no effective treatment for DXR …

Since its discovery and characterization in the early 1990s, a growing body of evidence
supports the involvement of endoglin in a broad range of patho-physiological conditions …

Background: Peritoneal fibrosis (PF) is an intractable complication in patients on long-term
peritoneal dialysis (PD). Transforming growth factor-β (TGF-β) is a key pro-fibrogenic factor …

Purpose: Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive soft-
tissue sarcomas that lack effective treatments, underscoring the urgent need to uncover …

The crosstalk between cancer and stromal cells plays a critical role in tumor progression.
Syntenin is a small scaffold protein involved in the regulation of intercellular communication …

Triple-negative breast cancer (TNBC) is characterized by the absence of the estrogen
receptor, progesterone receptor, and receptor tyrosine kinase HER2 expression. Due to the …