В обзоре представлены основополагающие данные современной литературы и
результаты собственных многолетних исследований роли ауто/паракринных факторов …

The ERBB proteins are cell membrane tyrosine kinase receptors. Among these receptors,
ERBB1 (EGFR or HER1) and ERBB2 (HER2/Neu) have been reported to be the most …

Background: Suitable diagnostics could identify patients who might benefit from targeted
therapies. Molecular imaging is a promising method estimating the expression of specific …

Proteins are the major targets of drug discovery and many of the new drugs are designed to
exert their effect by disrupting protein-protein interactions. Validation of the inhibition of …

Target expression heterogeneity and the presence of an immunosuppressive
microenvironment can hamper severely the efficiency of immunotherapeutic approaches …

ErbB2 is an important oncogenic protein involved in carcinogenesis of, among others,
breast, gastric, and ovarian carcinoma. Over-expression of ErbB2 is found in almost 20% of …

Background Human epidermal growth factor receptor-2 (Her-2) is over expressed in
approximately 25-30% of all primary breast tumors resulting in a distinctive breast cancer …

We showed previously that humanization of 528, a murine anti-epidermal growth factor
receptor (EGFR) antibody, causes reduced affinity for its target. Here, to improve the affinity …

Esophageal carcinoma is one of the most virulent malignant diseases and a major cause of
cancer-related deaths worldwide. Despite improvements in surgical techniques and …

Rhabdomyosarcomas (RMS) are tumors of the skeletal muscle lineage. Two main features
allow for distinction between subtypes: morphology and presence/absence of a …