Alcohol addiction is a chronic relapsing brain disease characterized by an impaired ability to
stop or control alcohol use despite adverse consequences. A main challenge of addiction …

Alcohol intake remains controlled in a majority of users but becomes “compulsive,” ie,
continues despite adverse consequences, in a minority who develop alcohol addiction …

Alcohol use disorder (AUD) is a multifaceted neuropsychiatric disease that combines
behavioral, psychosocial, and neurobiological aspects. Over the previous decade, animal …

Identifying biological markers predicting vulnerability to develop excessive alcohol
consumption may lead to a real improvement of clinical care. With converging evidence …

A key feature of compulsive alcohol drinking is continuing to drink despite negative
consequences. To examine the changes in neural activity that underlie this behavior …

Rationale In classical conditioning, sign-tracking reflects behavior directed toward a
conditioned stimulus (CS) in expectation of a reward (unconditioned stimulus, US); in …

Intermittent and excessive ethanol consumption over very short periods of time, known as
binge drinking, is common in the adolescence, considered a vulnerable period to the effects …

While most individuals with access to alcohol drink it recreationally, some vulnerable
individuals eventually lose control over their intake and progressively develop compulsive …

Protein kinase C epsilon (PKCε) regulates behavioural responses to ethanol and plays a
role in anxiety‐like behaviour, but knowledge is limited on downstream substrates of PKCε …

To more effectively manage substance use disorders, it is imperative to understand the
neural, genetic, and psychological underpinnings of addictive behavior. To contribute to this …