The neutrophil

GL Burn, A Foti, G Marsman, DF Patel, A Zychlinsky - Immunity, 2021 - cell.com
Neutrophils are immune cells with unusual biological features that furnish potent
antimicrobial properties. These cells phagocytose and subsequently kill prokaryotic and …

[HTML][HTML] Neutrophils and COVID-19: The road so far

LHA Cavalcante-Silva, DCM Carvalho… - International …, 2021 - Elsevier
The SARS-Cov2 infection triggers a multisystem inflammatory disorder, knowing as COVID-
19, a pandemic disease. This disease is characterized by acute respiratory distress …

The role of macrophages in the development of acute and chronic inflammatory lung diseases

JW Lee, W Chun, HJ Lee, JH Min, SM Kim, JY Seo… - Cells, 2021 - mdpi.com
Macrophages play an important role in the innate and adaptive immune responses of organ
systems, including the lungs, to particles and pathogens. Cumulative results show that …

The role of neutrophil extracellular traps in acute lung injury

D Scozzi, F Liao, AS Krupnick, D Kreisel… - Frontiers in …, 2022 - frontiersin.org
Acute lung injury (ALI) is a heterogeneous inflammatory condition associated with high
morbidity and mortality. Neutrophils play a key role in the development of different forms of …

Oxidative stress and inflammation in acute and chronic lung injuries

FS Bezerra, M Lanzetti, RT Nesi, AC Nagato, CP Silva… - Antioxidants, 2023 - mdpi.com
Acute and chronic lung injuries are among the leading causes of mortality worldwide. Lung
injury can affect several components of the respiratory system, including the airways …

[PDF][PDF] The vascular perspective on acute and chronic lung disease

I Borek, A Birnhuber, NF Voelkel… - Journal of Clinical …, 2023 - Am Soc Clin Investig
The pulmonary vasculature has been frequently overlooked in acute and chronic lung
diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and …

Selective activation of PFKL suppresses the phagocytic oxidative burst

N Amara, MP Cooper, MA Voronkova, BA Webb… - Cell, 2021 - cell.com
In neutrophils, nicotinamide adenine dinucleotide phosphate (NADPH) generated via the
pentose phosphate pathway fuels NADPH oxidase NOX2 to produce reactive oxygen …

The role of cytokines in neutrophil development, tissue homing, function and plasticity in health and disease

M Tsioumpekou, D Krijgsman, JHW Leusen… - Cells, 2023 - mdpi.com
Neutrophils are crucial innate immune cells and comprise 50–70% of the white blood cell
population under homeostatic conditions. Upon infection and in cancer, blood neutrophil …

Role of neutrophil extracellular traps in health and disease pathophysiology: recent insights and advances

MM Islam, N Takeyama - International Journal of Molecular Sciences, 2023 - mdpi.com
Neutrophils are the principal trouper of the innate immune system. Activated neutrophils
undergo a noble cell death termed NETosis and release a mesh-like structure called …

A new immortalized human alveolar epithelial cell model to study lung injury and toxicity on a breathing lung-on-chip system

A Sengupta, N Roldan, M Kiener, L Froment… - Frontiers in …, 2022 - frontiersin.org
The evaluation of inhalation toxicity, drug safety and efficacy assessment, as well as the
investigation of complex disease pathomechanisms, are increasingly relying on in vitro lung …