There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …

Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …

Melatonin is a naturally occurring molecule secreted by the pineal gland and known as a
gatekeeper of circadian clocks. Mounting evidence indicates that melatonin, employing …

Melatonin is a natural indoleamine produced by the pineal gland that has many functions,
including regulation of the circadian rhythm. Many studies have reported the anticancer …

Radio-and chemotherapy are the most common cancer treatment modalities. They cause
acute and late side effects on normal tissues, which is a burden for delivery of a high dose of …

Melatonin is present in virtually all organisms from bacteria to mammals, and it exhibits a
broad spectrum of biological functions, including synchronization of circadian rhythms and …

The development of most solid cancers, including pancreatic, breast, lung, liver, and ovarian
cancer, involves a desmoplastic reaction: a process of major remodeling of the extracellular …

Apocynin is a naturally occurring acetophenone, found in the roots of Apocynum
cannabinum and Picrorhiza kurroa. Various chemical and pharmaceutical modifications …

Highlights•Dysregulation of mitochondrial metabolism is a hallmark of cancer development.•
Nanoparticles (NPs) enable the efficient and targeted delivery of mitochondrial agents.•NPs …

Endoplasmic reticulum (ER) proteostasis is often altered in tumor cells due to intrinsic
(oncogene expression, aneuploidy) and extrinsic (environmental) challenges. ER stress …