Corticobasal degeneration (CBD) is a clinically heterogeneous tauopathy, which has
overlapping clinicopathologic and genetic characteristics with progressive supranuclear …

We have assessed the distribution of the tau H1/H2 haplotype in the publicly available
reference series of samples with representatives of most racial groups. This analysis shows …

The MAPT gene, encoding the microtubule-associated protein tau on chromosome 17q21.
31, is result of an inversion polymorphism, leading to two allelic variants (H1 and H2) …

Neurodegenerative disorders often acquire due to genetic predispositions and genomic
alterations after exposure to multiple risk factors. The most commonly found pathologies are …

Tauopathies, characterized by the dysfunction and aggregation of the microtubule-
associated protein tau (MAPT), represent some of the most devastating neurodegenerative …

Among the atypical parkinsonian syndromes, corticobasal degeneration (CBD) is probably
the most challenging disorder to diagnose antemortem. It can present with multiple …

Corticobasal degeneration (CBD) is a rare neurodegenerative disease characterized by the
predominance of pathological 4 repeat tau deposition in various cell types and anatomical …

The microtubule-associated protein tau (MAPT) H1 haplotype shows a strong association to
the sporadic neurodegenerative diseases, progressive supranuclear palsy and corticobasal …

Tau filaments with distinct morphologies and/or isoform compositions underlie a large
number of human neurodegenerative diseases. In conjunction with experimental studies …

An ancestral inversion of 900 kb on chromosome 17q21, which includes the microtubule-
associated protein tau (MAPT) gene, defines two haplotype clades in Caucasians (H1 and …