[HTML][HTML] Myeloid-derived suppressor cells: an emerging target for anticancer immunotherapy
Y Wu, M Yi, M Niu, Q Mei, K Wu - Molecular cancer, 2022 - Springer
The clinical responses observed following treatment with immune checkpoint inhibitors
(ICIs) support immunotherapy as a potential anticancer treatment. However, a large …
(ICIs) support immunotherapy as a potential anticancer treatment. However, a large …
[HTML][HTML] Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors
The development of combination immunotherapy based on the mediation of regulatory
mechanisms of the tumor immune microenvironment (TIME) is promising. However, a deep …
mechanisms of the tumor immune microenvironment (TIME) is promising. However, a deep …
[HTML][HTML] The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencing
C Wang, Q Yu, T Song, Z Wang, L Song… - … and Targeted Therapy, 2022 - nature.com
A thorough interrogation of the immune landscape is crucial for immunotherapy strategy
selection and prediction of clinical responses in non-small-cell lung cancer (NSCLC) …
selection and prediction of clinical responses in non-small-cell lung cancer (NSCLC) …
[HTML][HTML] Breast cancer heterogeneity and its implication in personalized precision therapy
L Guo, D Kong, J Liu, L Zhan, L Luo, W Zheng… - … hematology & oncology, 2023 - Springer
Breast cancer heterogeneity determines cancer progression, treatment effects, and
prognosis. However, the precise mechanism for this heterogeneity remains unknown owing …
prognosis. However, the precise mechanism for this heterogeneity remains unknown owing …
[HTML][HTML] Single cell cancer epigenetics
M Casado-Pelaez, A Bueno-Costa, M Esteller - Trends in Cancer, 2022 - cell.com
Bulk sequencing methodologies have allowed us to make great progress in cancer
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …
[HTML][HTML] Spatial multi-omics analyses of the tumor immune microenvironment
WC Hsieh, BR Budiarto, YF Wang, CY Lin… - Journal of Biomedical …, 2022 - Springer
In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-
immune microenvironment at the genomic, transcriptomic, and proteomic levels and have …
immune microenvironment at the genomic, transcriptomic, and proteomic levels and have …
[HTML][HTML] Advances in single-cell RNA sequencing and its applications in cancer research
D Huang, N Ma, X Li, Y Gou, Y Duan, B Liu… - Journal of hematology & …, 2023 - Springer
Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …
functional capabilities during the transition from a normal to a neoplastic state. Powerful …
[HTML][HTML] Artificial intelligence-assisted diagnostic cytology and genomic testing for hematologic disorders
L Gedefaw, CF Liu, RKL Ip, HF Tse, MHY Yeung… - Cells, 2023 - mdpi.com
Artificial intelligence (AI) is a rapidly evolving field of computer science that involves the
development of computational programs that can mimic human intelligence. In particular …
development of computational programs that can mimic human intelligence. In particular …
[HTML][HTML] A fibroblast-associated signature predicts prognosis and immunotherapy in esophageal squamous cell cancer
Q Ren, P Zhang, X Zhang, Y Feng, L Li, H Lin… - Frontiers in …, 2023 - frontiersin.org
Background Current paradigms of anti-tumor therapies are not qualified to evacuate the
malignancy ascribing to cancer stroma's functions in accelerating tumor relapse and …
malignancy ascribing to cancer stroma's functions in accelerating tumor relapse and …
Recent advances in high-throughput single-cell transcriptomics and spatial transcriptomics
X Shen, Y Zhao, Z Wang, Q Shi - Lab on a Chip, 2022 - pubs.rsc.org
Single-cell RNA sequencing (scRNA-seq) has been developed for characterizing the
transcriptome of cells that are rare but of biological significance. With cell barcoding and …
transcriptome of cells that are rare but of biological significance. With cell barcoding and …