Deconstruction of stable cross-Beta fibrillar structures into toxic and nontoxic products using a mutated archaeal chaperonin
Our group recently determined that a mutant archaeal chaperonin (Hsp 60) exhibited
substantially enhanced protein folding activity at low temperatures and was able to …
substantially enhanced protein folding activity at low temperatures and was able to …
Rapid self-association of highly amyloidogenic H-fragments of insulin: Experiment and molecular dynamics simulations
The so-called 'H-fragment'of insulin is an extremely amyloidogenic double chain peptide
consisting of the N-terminal parts of A-chain and B-chain linked by a disulfide bond between …
consisting of the N-terminal parts of A-chain and B-chain linked by a disulfide bond between …
Exploring the Propensities of Fluorescent Carbazole Analogs toward the Inhibition of Amyloid Aggregation in Type 2 Diabetes: An Experimental and Theoretical …
Amyloid aggregation is a pathological trait observed in many incurable and fatal
neurodegenerative and metabolic diseases associated with misfolding and self-assembly of …
neurodegenerative and metabolic diseases associated with misfolding and self-assembly of …
Spectroscopic evidence of tertiary structural differences between insulin molecules in fibrils
MM Schack, K Dahl, T Rades, M Groenning… - Journal of …, 2019 - Elsevier
Protein fibrils are of great interest due to their involvement in several pathologies and their
roles in the degradation of many therapeutic protein products. Fibrils share highly similar …
roles in the degradation of many therapeutic protein products. Fibrils share highly similar …
Advances, limitations, and prospects of biosensing technology for detecting phytopathogenic bacteria
Phytopathogenic bacteria cause severe economic losses in agricultural production
worldwide. The spread rates, severity, and emerging plant bacterial diseases have become …
worldwide. The spread rates, severity, and emerging plant bacterial diseases have become …
Structural studies of catalytic peptides using molecular dynamics simulations.
Many self-assembling peptides can form amyloid like structures with different sizes and
morphologies. Driven by non-covalent interactions, their aggregation can occur through …
morphologies. Driven by non-covalent interactions, their aggregation can occur through …
Deciphering UV Spectroscopy on Earth and Mars
R Roppel - 2024 - d-scholarship.pitt.edu
Spectroscopy consists of a variety of techniques that often probe materials with light. Light
can be absorbed and excite particular chromophores that give insight into electronic …
can be absorbed and excite particular chromophores that give insight into electronic …
FKBP22 from the psychrophilic bacterium Shewanella sp. SIB1 selectively binds to the reduced state of insulin to prevent its aggregation
FKBP22 of a psychrophilic bacterium, Shewanella sp. SIB1 (SIB1 FKBP22), is a member of
peptidyl-prolyl cis-trans isomerase (PPIase) and consists of N-and C-domains responsible …
peptidyl-prolyl cis-trans isomerase (PPIase) and consists of N-and C-domains responsible …
Amyloid Fibril Formation and Polymorphism: A Critical Role of Sulfur-Containing Amino Acid Residues
T Quiñones-Ruiz - 2022 - search.proquest.com
Protein aggregation that results in the formation of amyloid fibrils has been linked to many
neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. The …
neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. The …