The technology, opportunities and challenges of synthetic biological intelligence

BJ Kagan, C Gyngell, T Lysaght, VM Cole… - Biotechnology …, 2023 - Elsevier
Integrating neural cultures developed through synthetic biology methods with digital
computing has enabled the early development of Synthetic Biological Intelligence (SBI) …

[HTML][HTML] Patient-derived organoids in translational oncology and drug screening

R Yang, Y Yu - Cancer Letters, 2023 - Elsevier
Patient-derived organoids (PDO) are a new biomedical research model that can reconstruct
phenotypic and genetic characteristics of the original tissue and are useful for research on …

[HTML][HTML] Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish

L Smirnova, BS Caffo, DH Gracias, Q Huang… - Frontiers in …, 2023 - frontiersin.org
Biological computing (or biocomputing) offers potential advantages over silicon-based
computing in terms of faster decision-making, continuous learning during tasks, and greater …

Organoid intelligence (OI)–the ultimate functionality of a brain microphysiological system

L Smirnova, IEM Pantoja, T Hartung - ALTEX-Alternatives to animal …, 2023 - altex.org
Understanding brain function remains challenging as work with human and animal models
is complicated by compensatory mechanisms, while in vitro models have been too simple …

The promise and potential of brain organoids

L Smirnova, T Hartung - Advanced Healthcare Materials, 2024 - Wiley Online Library
Brain organoids are 3D in vitro culture systems derived from human pluripotent stem cells
that self‐organize to model features of the (developing) human brain. This review examines …

Revisiting the role of HR in the age of AI: bringing humans and machines closer together in the workplace

A Fenwick, G Molnar, P Frangos - Frontiers in Artificial Intelligence, 2024 - frontiersin.org
The functions of human resource management (HRM) have changed radically in the past 20
years due to market and technological forces, becoming more cross-functional and data …

Microinstrumentation for brain organoids

D Patel, S Shetty, C Acha, IEM Pantoja… - Advanced …, 2024 - Wiley Online Library
Brain organoids are three‐dimensional aggregates of self‐organized differentiated stem
cells that mimic the structure and function of human brain regions. Organoids bridge the …

Asteroid impact: the potential of astrocytes to modulate human neural networks within organoids

SS Lavekar, MD Patel, MD Montalvo-Parra… - Frontiers in …, 2023 - frontiersin.org
Astrocytes are a vital cellular component of the central nervous system that impact neuronal
function in both healthy and pathological states. This includes intercellular signals to …

Brain organoids: are they for real?

R Quirion - Frontiers in Science, 2023 - frontiersin.org
In 1965, Gordon E. Moore, the co-founder of Intel, observed that the number of transistors on
a single microchip doubles approximately every two years, while the cost of computers …

Versatile micro-electrode array to monitor human iPSC derived 3D neural tissues at air-liquid interface

L Stoppini, MO Heuschkel, C Loussert-Fonta… - Frontiers in Cellular …, 2024 - frontiersin.org
Engineered 3D neural tissues made of neurons and glial cells derived from human induced
pluripotent stem cells (hiPSC) are among the most promising tools in drug discovery and …