Placental transfer of maternal IgG antibodies to the fetus is an important mechanism that
provides protection to the infant while his/her humoral response is inefficient. IgG is the only …

Immunoglobulins form an important component of the immunological activity found in milk
and colostrum. They are central to the immunological link that occurs when the mother …

Background The candidate malaria vaccine RTS, S/AS01 reduced episodes of both clinical
and severe malaria in children 5 to 17 months of age by approximately 50% in an ongoing …

Natural antibodies (NAb) are defined as germline encoded immunoglobulins found in
individuals without (known) prior antigenic experience. NAb bind exogenous (eg, bacterial) …

BACKGROUND: Vaccination against pertussis during pregnancy is recommended to protect
newborns, yet there is limited information about the effectiveness of maternal tetanus toxoid …

Background Rotavirus gastroenteritis causes many deaths in infants in sub-Saharan Africa.
Because rotavirus vaccines have proven effective in developed countries but had not been …

Oral vaccines are less immunogenic when given to infants in low-income compared with
high-income countries, limiting their potential public health impact. Here, we review factors …

Infants and the elderly share a high vulnerability to infections and therefore have specific
immunization requirements. Inducing potent and sustained B-cell responses is as …

Pediatric vaccines have significantly reduced infectious disease–related infant mortality, but
as protective immunity often requires several infant vaccine doses, maternally acquired Abs …

To generate vaccine-mediated protection is a complex challenge. Currently available
vaccines have largely been developed empirically, with little or no understanding on how …