[HTML][HTML] Rapid fluid removal during dialysis is associated with cardiovascular morbidity and mortality

JE Flythe, SE Kimmel, SM Brunelli - Kidney international, 2011 - Elsevier
Patients receiving hemodialysis have high rates of cardiovascular morbidity and mortality
that may be related to the hemodynamic effects of rapid ultrafiltration. Here we tested …

The use of a multidimensional measure of dialysis adequacy—moving beyond small solute kinetics

J Perl, LM Dember, JM Bargman… - Clinical Journal of the …, 2017 - journals.lww.com
Urea removal has become a key measure of the intensity of dialysis treatment for kidney
failure. Small solute removal, exemplified by Kt/V urea, has been broadly applied as a …

[HTML][HTML] Longer treatment time and slower ultrafiltration in hemodialysis: associations with reduced mortality in the DOPPS

R Saran, JL Bragg-Gresham, NW Levin… - Kidney international, 2006 - Elsevier
Longer treatment time (TT) and slower ultrafiltration rate (UFR) are considered
advantageous for hemodialysis (HD) patients. The study included 22 000 HD patients from …

Dialysate sodium: rationale for evolution over time

JE Flythe, FR Mc Causland - Seminars in dialysis, 2017 - Wiley Online Library
Oligo‐anuric individuals receiving hemodialysis (HD) are dependent on the dialysis
machine to regulate sodium and water balance. Interest in adjusting the dialysate sodium …

Association between high ultrafiltration rates and mortality in uraemic patients on regular haemodialysis. A 5-year prospective observational multicentre study

E Movilli, P Gaggia, R Zubani… - Nephrology Dialysis …, 2007 - academic.oup.com
Background. High ultrafiltration rate on haemodialysis (HD) stresses the cardiovascular
system and could have a negative effect on survival. Methods. The effect of ultrafiltration rate …

Disentangling the ultrafiltration rate–mortality association: The respective roles of session length and weight gain

JE Flythe, GC Curhan, SM Brunelli - Clinical Journal of the …, 2013 - journals.lww.com
Results Compared with delivered session length≥ 240, session length< 240 minutes was
associated with increased all-cause mortality (adjusted hazard ratio [95% confidence …

Associations of posthemodialysis weights above and below target weight with all-cause and cardiovascular mortality

JE Flythe, AV Kshirsagar, RJ Falk… - Clinical Journal of the …, 2015 - journals.lww.com
Results Above target weight miss in at least 30% of treatments (versus not) was associated
with greater all-cause mortality (adjusted hazard ratio, 1.28; 95% confidence interval, 1.15 to …

Association of ultrafiltration rate with mortality in incident hemodialysis patients

TW Kim, TI Chang, TH Kim, JA Chou, M Soohoo… - Nephron, 2018 - karger.com
Abstract Background/Aims: Ultrafiltration rate (UFR) appears to be associated with mortality
in prevalent hemodialysis (HD) patients. However, the association of UFR with mortality in …

The risks of high ultrafiltration rate in chronic hemodialysis: implications for patient care

JE Flythe, SM Brunelli - Seminars in dialysis, 2011 - Wiley Online Library
As dialytic practice has evolved, hemodialysis (HD) adequacy has come to be defined in
terms of small molecule clearance. A growing body of evidence suggests that fluid …

Downregulation of miRNA‐30a enhanced autophagy in osthole‐alleviated myocardium ischemia/reperfusion injury

S Liu, Y He, J Shi, L Liu, H Ma, L He… - Journal of Cellular …, 2019 - Wiley Online Library
Osthole could alleviate myocardial ischemia/reperfusion (I/R) injury. However, the
underlying mechanism remains unclear. In this study, we explored whether microRNA (miR) …