A large number of pharmacological studies have used capsaicin as a tool to activate many
physiological systems, with an emphasis on pain research but also including functions such …

Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient
receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved …

Approximately 20 of the 30 mammalian transient receptor potential (TRP) channel subunits
are expressed by specific neurons and cells within the alimentary canal. They subserve …

Transient Receptor Potential Ankyrin 1 (TRPA1) channels are localized on sensory nerves
and several non-neural cells, but data on their functional significance are contradictory. We …

TRPV1 has been originally cloned as the heat and capsaicin receptor implicated in acute
pain signalling, while further research has shifted the focus to its importance in chronic pain …

We investigated immunohistochemical differences in the distribution of TRPV1 channels and
the contractile effects of capsaicin on smooth muscle in the mouse rectum and distal …

Background Mediators released in the mucosal milieu have been suggested to be involved
in visceral hypersensitivity and abdominal pain in patients with irritable bowel syndrome …

The dried flowers of Chamaemelum nobile (L.) All. have been used in traditional medicine
for different conditions related to the spasm of the gastrointestinal system. However, there …

In the gut, transient receptor potential vanilloid (TRPV) 1 activation leads to release of
neurotransmitters such as neuropeptides and nitric oxide. However, the distribution of …

Background and purpose: The functional roles of M2 and M3 muscarinic receptors in
neurogenic cholinergic contractions in gastrointestinal tracts remain to be elucidated. To …