M2 and M3 muscarinic receptors are involved in enteric nerve-mediated contraction of the mouse ileum: findings obtained with muscarinic-receptor knockout mouse

T Takeuchi, K Tanaka, H Nakajima… - American Journal …, 2007 - journals.physiology.org
The involvement of muscarinic receptors in neurogenic responses of the ileum was studied
in wild-type and muscarinic-receptor (M-receptor) knockout (KO) mice. Electrical field …

Capsaicin alleviates abnormal intestinal motility through regulation of enteric motor neurons and MLCK activity: Relevance to intestinal motility disorders

D Chen, Y Xiong, Y Lin, Z Tang, J Wang… - Molecular nutrition & …, 2015 - Wiley Online Library
Scope Capsaicin is an active component of chili peppers, having diverse effects. However,
the effects of capsaicin on intestinal motility are still controversial. The present study aimed …

Characterization of the EP receptor types that mediate longitudinal smooth muscle contraction of human colon, mouse colon and mouse ileum

SE Fairbrother, JE Smith, RA Borman… - …, 2011 - Wiley Online Library
Abstract Background Prostaglandin E2 (PGE2) is an inflammatory mediator implicated in
several gastrointestinal pathologies that affect normal intestinal transit. The aim was to …

[HTML][HTML] Capsaicin Causes Vasorelaxation of Rat Aorta through Blocking of L-type Ca2+ Channels and Activation of CB1 Receptors

F Andrade, C Rangel-Sandoval… - Molecules, 2020 - mdpi.com
The aim of this work was to determine whether Capsaicin may exert a vascular regulation
through the activation of CB1 and/or CB2 receptors causing vasorelaxation in the rat aorta …

Functional study on TRPV1‐mediated signalling in the mouse small intestine: involvement of tachykinin receptors

JG De Man, S Boeckx, S Anguille… - …, 2008 - Wiley Online Library
Afferent nerves in the gut not only signal to the central nervous system but also provide a
local efferent‐like effect. This effect can modulate intestinal motility and secretion and is …

Inhibitory effect of Iboga-type indole alkaloids on capsaicin-induced contraction in isolated mouse rectum

MW Lo, K Matsumoto, M Iwai, K Tashima… - Journal of natural …, 2011 - Springer
Voacanga africana (Apocynaceae) is used as an anti-diarrheal medicine in West Africa. In
the present study, we investigated the effect of an extract of V. africana and its constituents …

[HTML][HTML] Propolis alleviates ulcerative colitis injury by inhibiting the protein kinase C‐transient receptor potential cation channel subfamily V member 1‐calcitonin gene …

Z Qian, M Zhang, T Lu, J Yu, S Yin, H Wang, J Wang - Plos one, 2024 - journals.plos.org
This study investigated the protective effect of water-soluble propolis (WSP) on colonic
tissues in ulcerative colitis (UC) and the role of the protein kinase C‐transient receptor …

Co-localization of TRPV1-expressing nerve fibers with calcitonin-gene-related peptide and substance P in fundus of rat stomach

S Horie, GJ Michael, JV Priestley - Inflammopharmacology, 2005 - Springer
The localization of vanilloid receptor TRPV1 was studied in rat gastric fundus by an
immunohistochemical technique. Numerous TRPV1-immunoreactive nerve fibers were …

Intrathecal injection of TRPV1 shRNA leads to increases in blood pressure in rats

SQ Yu, DH Wang - Acta physiologica, 2011 - Wiley Online Library
Aim: The transient receptor potential vanilloid type 1 (TRPV1) channels have been
implicated to play a role in blood pressure regulation. However, contribution of tissue …

The transient receptor potential vanilloid receptor 1, TRPV1 (VR1) inhibits peristalsis in the mouse jejunum

R Rahmati - Archives of Iranian medicine, 2012 - journalaim.com
BACKGROUND: The transient receptor potential vanilloid receptor 1, TRPV1 [previously
termed the capsaicin or vanilloid receptor 1 (VR1)] is a nonselective cation channel that has …