SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves
defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator …

Self-reactive B cells are eliminated in a series of checkpoints that are triggered by antigen
binding. Recent reports have shown that in addition to the processes of elimination at the …

Anergic self-reactive B cells competing within a polyclonal B cell repertoire fail to migrate
into primary follicles and die after l-3 days residence in T cell zones. Transfer of anergic HEL …

Self-reactive B cells from tolerant double-transgenic (Dbl-Tg) mice coexpressing hen egg
lysozyme (HEL) and rearranged anti-HEL immunoglobulin genes have a relatively short life …

The BLyS family of ligands and receptors governs B cell homeostasis by controlling survival,
differentiation, and lifespan. This family consists of multiple receptors and ligands, allowing …

Debate has surrounded the subject of B cell life span since it was first measured in mice in
the early 1970s. In the 25 years which have passed since then, it has become increasingly …

Recent advances in the understanding of the collaboration between T cells and B cells have
provided a novel framework within which to analyse the mechanisms of B-cell tolerance and …

Lymphocyte homeostasis encompasses a continuum of processes that together determine
the production, turnover, composition, and representation of lymphocyte pools. These …

One of the challenges in the study of autoimmunity is to understand which autoreactive cells
are subject to regulation and what mechanisms of regulation are operative. In mice …

Natural Abs specific for the carbohydrate Ag Galα1–3Galβ1–4GlcNAc-R (αGal) play an
important role in providing protective host immunity to various pathogens; yet little is known …