Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular
clocks, which serve to coordinate internal time with the external world. The circadian system …

The basal forebrain cholinergic system (BFCS) has long been implicated in age-related
cognitive changes and the pathophysiology of Alzheimer's disease (AD). Limitations of …

Circadian modulation of learning and memory efficiency is an evolutionarily conserved
phenomenon, occurring in organisms ranging from invertebrates to higher mammalian …

The master clock in the suprachiasmatic nucleus (SCN) of the hypothalamus provides a
temporal pattern of sleep and wake that-like many other behavioural and physiological …

Simple Summary Circadian rhythms, driven by molecular clockwork, exist in nearly all cells
and tissues throughout the body, and these rhythmic oscillators constitute tightly coupled …

Alzheimer's disease (AD) is increasing in prevalence and has a significant impact on
caregivers and the healthcare system. One of the many physiologic process affected by AD …

Deep brain stimulation (DBS) of nucleus basalis of Meynert (NBM) is currently being
evaluated as a potential therapy to improve memory and overall cognitive function in …

Traumatic brain injury (TBI) is a complex and costly worldwide phenomenon that can lead to
many negative health outcomes including disrupted circadian function. There is a …

In recent years, neuropeptides which display potent regulatory control of stress-related
behaviors have been extensively demonstrated to play a critical role in regulating behaviors …

Circadian rhythms in nocturnal and diurnal mammals are primarily synchronized to local
time by the light/dark cycle. However, nonphotic factors, such as behavioral arousal and …