Immunometabolism, which is the metabolic reprogramming of anaerobic glycolysis,
oxidative phosphorylation, and metabolite synthesis upon immune cell activation, has …

Oxidative stress is a major contributor to the pathogenesis of various inflammatory diseases.
Accumulating evidence has shown that oxidative stress is characterized by the …

Protein import into mitochondria is a highly regulated process, yet how cells clear
mitochondria undergoing dysfunctional protein import remains poorly characterized. Here …

Kidney tubular epithelial cells (TECs) have a crucial role in the damage and repair response
to acute and chronic injury. To adequately respond to constant changes in the environment …

Over the last decade, significant progress has been achieved in defining mechanisms
underlying NLR regulation of immune system function. However, several NLR family …

A complex interaction exists between elements of the host innate immune system and viral
pathogens. It is essential that the host mount a robust immune response during viral …

Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and
chronic kidney disease. NLRX1 is a receptor of the innate immune system that is …

Objective: The migration and invasion features, which were associated with inflammatory
response, acted as vital roles in the development of colon cancer. Quercetin, a bioflavonoid …

The immune system of vertebrates confers protective mechanisms to the host through the
sensing of stress-induced agents expressed during infection or cell stress. Among them, the …

NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique
pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting …