Traumatic and nontraumatic brain injury results from severe disruptions in the cellular
microenvironment leading to massive loss of neuronal populations and increased …

Cells utilize a diverse repertoire of cell surface and intracellular receptors to detect
exogenous or endogenous danger signals and even the changes of their microenvironment …

Nucleotide binding and oligomerization domain (NOD)-like receptor (NLR) initially appeared
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …

The mitochondrial Nod-like receptor protein NLRX1 protects against colorectal
tumorigenesis through mechanisms that remain unclear. Using mice with an intestinal …

An increased level of proinflammatory cytokines, including TNF-α in tumor microenvironment
regulates the bioenergetic capacity, immune evasion and survival of cancer cells. Emerging …

Pancreatic cancer is a deadly malignancy with limited treatment options. NLRX1 is a unique,
understudied member of the Nod-like Receptor (NLR) family of pattern recognition receptors …

NLRX1, the mitochondrial NOD-like receptor (NLR), modulates apoptosis in response to
both intrinsic and extrinsic cues. Insights into the mechanism of how NLRX1 influences …

The role of mitochondria is emerging in regulation of innate immunity, inflammation and cell
death beyond its primary role in energy metabolism. Mitochondria act as molecular platform …

Osteoarthritis (OA) is a chronic debilitating disease characterized by joint degeneration.
Excessive chondrocyte apoptosis and inflammation contributes to articular cartilage …

Histiocytic sarcoma is an uncommon malignancy in both humans and veterinary species.
Research exploring the pathogenesis of this disease is scarce; thus, diagnostic and …